Results 61 to 70 of about 331,887 (241)

Is Generative AI an Ally or Foe for Human Resources?

Maketingu Janaru
In this study, an internet survey was conducted as a two-wave survey among practitioners in human resources (HR) departments to determine the actual use of generative AI in HR work.
Takashi Nishimura
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Molecular property prediction in the ultra‐low data regime

Communications Chemistry
Data scarcity remains a major obstacle to effective machine learning in molecular property prediction and design, affecting diverse domains such as pharmaceuticals, solvents, polymers, and energy carriers.
Basem A. Eraqi, Dmitrii Khizbullin, Shashank S. Nagaraja, S. Mani Sarathy   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Generative Artificial Intelligence in Tertiary Education: Assessment Redesign Principles and Considerations

Education Sciences
The emergence of generative artificial intelligence (AI) such as ChatGPT has sparked significant assessment concerns within tertiary education. Assessment concerns have largely revolved around academic integrity issues among students, such as plagiarism ...
Che Yee Lye, Lyndon Lim
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Generative AI (Artificial Intelligence): What Is It? & What Are Its Inter- And Transdisciplinary Applications? [PDF]

Journal of Systemics, Cybernetics and Informatics
Generative AI can generate new contents in many types of outputs: images, videos, text or music. ChatGPT is web application that uses Generative AI. Many industries such as financial, health care, manufacturing, and marketing and sales use Generative AI.
Richard S. Segall
doaj  

Generative artificial intelligence dependency: Scale development, validation, and its motivational, behavioral, and psychological correlates

Computers in Human Behavior Reports
As generative Artificial Intelligence (AI) becomes increasingly integrated into daily life, concerns have emerged about growing dependency on AI and its potential psychological and behavioral consequences.
Adalia Y.H. Goh, Andree Hartanto, Nadyanna M. Majeed   +2 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source