Results 201 to 210 of about 154,226 (313)

3D printed plates based on generative design biomechanically outperform manual digital fitting and conventional systems printed in photopolymers in bridging mandibular bone defects of critical size in dogs. [PDF]

Front Vet Sci, 2023
Baumgartner D, Schramel JP, Kau S, Unger E, Oberoi G, Peham C, Eberspächer-Schweda M.   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluating BindCraft for Generative Design of High-Affinity Peptides. [PDF]

ACS Chem Biol
Filius M, Patsos T, Minnee H, Turco G, Chong HE, Liu J, Gnatzy M, Rooth RSM, Liu ACH, Ta RDT, Rijk IHA, Ziani S, Boxman FJ, Pomplun SJ.   +13 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Generative Design of 3D-Printed Biomimetic Interlocking Blocks Inspired by the Cellular 3D Puzzle Structure of the Walnut Shell. [PDF]

Biomimetics (Basel)
Efstathiadis A, Symeonidou I, Tsongas K, Tzimtzimis EK, Tzetzis D.   +4 more
europepmc   +1 more source

Deep generative design of porous organic cages via a variational autoencoder.

Digit Discov, 2023
Zhou J, Mroz A, Jelfs KE.
europepmc   +1 more source

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices. [PDF]

Adv Sci (Weinh), 2021
He Y, Abdi M, Trindade GF, Begines B, Dubern JF, Prina E, Hook AL, Choong GYH, Ledesma J, Tuck CJ, Rose FRAJ, Hague RJM, Roberts CJ, De Focatiis DSA, Ashcroft IA, Williams P, Irvine DJ, Alexander MR, Wildman RD.   +18 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

MOFGPT: Generative Design of Metal-Organic Frameworks using Language Models. [PDF]

J Chem Inf Model
Badrinarayanan S, Magar R, Antony A, Meda RS, Barati Farimani A.   +4 more
europepmc   +1 more source

Generative Design Research Methods for Sustainability: Graduate Research and Design Interventions on Effective Use of Water [PDF]

This paper presents a course model, Generative Design for Sustainability, that brings together Experience Chart (EC) guide as a user observation method and two generative research methods, namely Design for User Intention (DUI) and Experience Reflection ...
Dilruba, Oğur,, Çağla, Doğan,, Turhan, Senem,   +2 more
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