Results 71 to 80 of about 405,858 (264)
EvoDevo: Bioinspired Generative Design via Evolutionary Graph-Based Development
AlgorithmsAutomated generative design is increasingly used across engineering disciplines to accelerate innovation and reduce costs. Generative design offers the prospect of simplifying manual design tasks by exploring the efficacy of solutions automatically ...
Farajollah Tahernezhad-Javazm +8 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
DesignsThis review explores the intersection of Artificial Intelligence (AI) and Generative Design (GD) in engineering within the mechanical, industrial, civil, and architectural domains.
Owen Peckham +7 more
doaj +1 more source
General Design Bayesian Generalized Linear Mixed Models
Statistical Science, 2006 Published at http://dx.doi.org/10.1214/088342306000000015 in the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Zhao, Yihua +3 more
openaire +4 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Generative Design of Concentrated Solar Thermal Tower Receivers—State of the Art and Trends
EnergiesThe rapid advances in artificial intelligence (AI) and high-performance computing (HPC) are transforming the landscape of engineering design, and the concentrated solar power (CSP) tower sector is no exception.
Jorge Moreno García-Moreno +1 more
doaj +1 more source
Design space reduction in optimization using generative topographic mapping
, 2009 Dimension reduction in design optimization is an extensively researched area. The need arises in design problems dealing with very high dimensions, which increase the computational burden of the design process because the sample space required for the ...
Forrester, Alexander +2 more
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Compositional design of a generic design agent
Design Studies, 2001 This paper presents a generic architecture for a design agent, to be used in an Internet environment. The design agent is based on an existing generic agent model, and includes a refinement of a generic model for design, in which strategic reasoning and dynamic management of requirements are explicitly modelled.
Brazier, F.M. +3 more
openaire +5 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Improving the Design and Implementation of Software Systems uses Aspect Oriented Programming [PDF]
A design pattern is used as a static reusable component of object oriented design in the many patterns catalogue. The regular design pattern does not show any collaboration of shared resource between patterns in the software design. But generative design
Allen, Gary +2 more
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