Results 81 to 90 of about 133,835 (264)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Evolving Memory in Gene Regulatory Networks for Artificial Growth

IEEE Access
Using simple artificial evolution to assist in the design of complex engineering systems has a number of issues regarding diversity, scalability etc.
Colin Roitt, Simon Hickinbotham, Edgar Buchanan, Andy M. Tyrrell   +3 more
doaj   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Human–AI Collaborative Design in Architectural Studios: Evaluating Paradigm Shifts Across the Six Stages of the Design Process

Buildings
Artificial intelligence (AI) is increasingly transforming architectural education, shifting design studios toward human–AI collaborative workflows. This study investigates the impact of AI integration across the six stages of the architectural design ...
Hend Alana, Mohamed Fikry, Asmaa Hasan
doaj   +1 more source

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

Analysis of the Energy Optimization Method of Apartment Buildings by Using Generative Design in Terms of Integrated Design

Applied Sciences
Improving building energy efficiency has become essential for reducing global greenhouse gas emissions. (1) Background: We aim to strengthen early-stage collaboration among stakeholders based on integrated design principles, rather than relying solely on
So-Yeon Kim, Jong-Ho Lee
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Methodological Framework for Semiconductor Fab Design Using Dynamo-Based Generative Design

Applied Sciences
The rapid growth of the semiconductor industry has created a bottleneck in which traditional manual methods for designing fabrication plants (fabs) cannot keep pace with their high complexity and short technological lifecycles.
Yeongyu Hwang, WonSeok Choi, Minhyuk Jung, Wonho Cho, Jaewook Lee   +4 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Generative Design in Urban Planning with Regard to Local Zoning Regulations: A BIM Case Study

Urban Science
The development of Building Information Modeling (BIM) and Generative Design (GD) methods supported by artificial intelligence opens up new possibilities in the field of urban planning analyses and the verification of land-use compliance with local ...
Andrzej Szymon Borkowski, Filip Pawlikowski, Anna Ptaszek, Patrycja Raczkowska, Wiktoria Winiarska, Natalia Wyrzykowska   +5 more
doaj   +1 more source