Results 101 to 110 of about 422,386 (278)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Analysis of the Energy Optimization Method of Apartment Buildings by Using Generative Design in Terms of Integrated Design

Applied Sciences
Improving building energy efficiency has become essential for reducing global greenhouse gas emissions. (1) Background: We aim to strengthen early-stage collaboration among stakeholders based on integrated design principles, rather than relying solely on
So-Yeon Kim, Jong-Ho Lee
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Methodological Framework for Semiconductor Fab Design Using Dynamo-Based Generative Design

Applied Sciences
The rapid growth of the semiconductor industry has created a bottleneck in which traditional manual methods for designing fabrication plants (fabs) cannot keep pace with their high complexity and short technological lifecycles.
Yeongyu Hwang, WonSeok Choi, Minhyuk Jung, Wonho Cho, Jaewook Lee   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Category-Theory-Guided Conditional Diffusion Modeling for Climate-Responsive Architectural Spatial Layout Generation

Buildings
Achieving robust environmental responsiveness in early stage architectural spatial layout design remains a critical challenge under the imperatives of global carbon neutrality and climate-adaptive building practice.
Rui Liu, Xiaofei Lu
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Human–AI Collaborative Design in Architectural Studios: Evaluating Paradigm Shifts Across the Six Stages of the Design Process

Buildings
Artificial intelligence (AI) is increasingly transforming architectural education, shifting design studios toward human–AI collaborative workflows. This study investigates the impact of AI integration across the six stages of the architectural design ...
Hend Alana, Mohamed Fikry, Asmaa Hasan
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Generative design and its role in developing the design of cans and packaging

الاكاديمي
In the current study (generative design and its role in developing the design of cans and packaging), the researcher studied generative design and its role in developing the field of can and packaging design, which saves the effort and time needed to ...
Suha Mahmoud Taha, Ali Ghazi Matar
doaj   +1 more source