Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Single-Generator Generalized Cyclic Factorial Designs as Pseudofactor Designs
The Annals of Statistics, 1988 The class of single-generator generalized cyclic designs is shown to be degrees of freedom equivalent to a subclass of the class of prime-level pseudofactor designs.
openaire +3 more sources
Generative feature-based design-by-constraints as a means of integration within the manufacturing industry [PDF]
, 1991 The article examines the development of computer aids within manufacturing industry and proposes an alternative approach to the way we design and the designer's role within manufacturing.
Jaques, MWS +5 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
AI-assisted design of lightweight and strong 3D-printed wheels for electric vehicles.
PLoS ONEThe automotive industry is undergoing a transformative shift towards electric vehicles (EVs), driven by environmental concerns and technological advancements.
Timileyin Opeyemi Akande +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
EvoDevo: Bioinspired Generative Design via Evolutionary Graph-Based Development
AlgorithmsAutomated generative design is increasingly used across engineering disciplines to accelerate innovation and reduce costs. Generative design offers the prospect of simplifying manual design tasks by exploring the efficacy of solutions automatically ...
Farajollah Tahernezhad-Javazm +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
DesignsThis review explores the intersection of Artificial Intelligence (AI) and Generative Design (GD) in engineering within the mechanical, industrial, civil, and architectural domains.
Owen Peckham +7 more
doaj +1 more source
Design and analysis of light weight swing arm using generative design concept [PDF]
E3S Web of ConferencesA Swing arm is a mechanical device that connects the rear wheel of the motorcycle to its body, allowing it to pivot vertically. It holds the rear axle firmly while pivoting to absorb bumps and suspension loads induced by acceleration and braking.
Gupta G. Srinivasa +2 more
doaj +1 more source