Results 101 to 110 of about 133,835 (264)
Enhancing mechanical and bioinspired materials through generative AI approaches
Next MaterialsThe integration of generative artificial intelligence (AI) into the design and additive manufacturing processes of mechanical and bioinspired materials has emerged as a transformative approach in engineering and material science, allowing to explore ...
Silvia Badini +2 more
doaj +1 more source
, 2017 Today it is increasingly essential to fully understand the potential of the software, now able to let us hire more awareness in the control of the project, but especially in the potential of new forms of development. Evolved codes and programming languages are already available and, as well as giving many ideational possibilities, place their ...
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Probabilistic generative transformer language models for generative design of molecules. [PDF]
J Cheminform, 2023 Wei L, Fu N, Song Y, Wang Q, Hu J.
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Generative Design of Structured Materials for Controlled Frequency Responses. [PDF]
3D Print Addit Manuf, 2023 Yang W, Huang L, Singamneni S.
europepmc +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
GENERATIVE DESIGN IN CULTURAL FLUX: SPATIOTEMPORAL DYNAMICS AND VALUE METRICS
Russian Studies in Culture and SocietyCulture, as the core dimension for value manifestation in generative design, exerts decisive influence on design morphology through its spatiotemporal attributes and structural characteristics.
Wei Weng
doaj +1 more source