Results 111 to 120 of about 154,226 (313)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Generative Design of Concentrated Solar Thermal Tower Receivers—State of the Art and Trends

Energies
The rapid advances in artificial intelligence (AI) and high-performance computing (HPC) are transforming the landscape of engineering design, and the concentrated solar power (CSP) tower sector is no exception.
Jorge Moreno García-Moreno, Kypros Milidonis   +1 more
doaj   +1 more source

An aerospace component cost modelling study for value driven design [PDF]

, 2009
Demand is increasing in aero-engine products for better efficiency and environmental performance whilst keeping the cost low. Unlike performance, the physics behind cost is least understood.
Cheung, J. M. W., Wiseall, S.S., Scanlan, J. P., Wiseall, S. S., Cheung, J.M.W., Scanlan, J.P.   +5 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An Initial Model for Generative Design Research: Bringing together Generative Focus Group (GFG) and Experience Reflection Modelling (ERM) [PDF]

, 2015
Understanding people’s experiences and the context of use of a product at the earliest stages of the design process has in the last decade become an important aspect of both the design profession and design education.
TURHAN, Senem, BAKIRLIOĞLU, Yekta, Bakırlıoğlu, Yekta, OĞUR, Dilruba, DOĞAN, Çağla   +4 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Generative design for individual orthopaedic insoles: Optimisation of load distribution and additive manufacturing

Current Directions in Biomedical Engineering
Introduction: Generative Design (GD) is an intelligent process that uses algorithms to automatically create optimised, functional and material-efficient structures based on defined parameters and loads. This makes it a valuable tool for the customisation
Schneider Julia, Bouffier Justus, Valerga Puerta Ana Pilar, Völz Diana   +3 more
doaj   +1 more source

Crafting Soft Wearables, with and through digital technologies

Temes de Disseny, 2019
As wearables and e-textiles enter into another hype cycle (Tomico et al. 2017), we find ourselves with the opportunity to reflect on the work done and the work remaining.
Bruna Goveia da Rocha, Kristina Andersen, Oscar Tomico   +2 more
doaj   +1 more source

Generative Components [PDF]

, 2006
Generative Components is the name given to a new kind of computer-aided-design software being pioneered by Bentley Microstation, and which is currently being beta-tested by leading international architectural practices such as Foster and Partners or Kohn
Martin, A., Hardy, S., Berglund, J., Yau, A.   +3 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source