Results 111 to 120 of about 10,007,622 (296)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Journal of Asian Architecture and Building EngineeringThis paper proposes a method for floor plan designs that combines shape grammar with Building Information Modeling (BIM) technology to create plan module libraries by using the mass modular housing project in ShanLiChenJia village as an example.
Jiang Wang, Jiandong Zhou, Sheng Zhang
doaj +1 more source
BuildingsAchieving robust environmental responsiveness in early stage architectural spatial layout design remains a critical challenge under the imperatives of global carbon neutrality and climate-adaptive building practice.
Rui Liu, Xiaofei Lu
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evolving Memory in Gene Regulatory Networks for Artificial Growth
IEEE AccessUsing simple artificial evolution to assist in the design of complex engineering systems has a number of issues regarding diversity, scalability etc.
Colin Roitt +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
BuildingsArtificial intelligence (AI) is increasingly transforming architectural education, shifting design studios toward human–AI collaborative workflows. This study investigates the impact of AI integration across the six stages of the architectural design ...
Hend Alana, Mohamed Fikry, Asmaa Hasan
doaj +1 more source
Advancing Design With Generative AI: A Case of Automotive Design Process Transformation
Generative AI has greatly enhanced the production of digital content and has had a significant impact on the creative activities of designers. However, generalized generative AI falls short of designers\u27 expectations in semantic understanding and ...
Li, Yeye +4 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Applied SciencesImproving building energy efficiency has become essential for reducing global greenhouse gas emissions. (1) Background: We aim to strengthen early-stage collaboration among stakeholders based on integrated design principles, rather than relying solely on
So-Yeon Kim, Jong-Ho Lee
doaj +1 more source