Results 111 to 120 of about 133,835 (264)

Perfect prosthetic heart valve: generative design with machine learning, modeling, and optimization. [PDF]

Front Bioeng Biotechnol, 2023
Danilov VV, Klyshnikov KY, Onishenko PS, Proutski A, Gankin Y, Melgani F, Ovcharenko EA.   +6 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Open Macromolecular Genome: Generative Design of Synthetically Accessible Polymers. [PDF]

ACS Polym Au, 2023
Kim S, Schroeder CM, Jackson NE.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Generative design and its role in developing the design of cans and packaging

الاكاديمي
In the current study (generative design and its role in developing the design of cans and packaging), the researcher studied generative design and its role in developing the field of can and packaging design, which saves the effort and time needed to ...
Suha Mahmoud Taha, Ali Ghazi Matar
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Generative design for COVID-19 and future pathogens using stochastic multi-agent simulation. [PDF]

Sustain Cities Soc, 2023
Lee B, Lau D, Mogk JPM, Lee M, Bibliowicz J, Goldstein R, Tessier A.   +6 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

AI-assisted design of lightweight and strong 3D-printed wheels for electric vehicles.

PLoS ONE
The automotive industry is undergoing a transformative shift towards electric vehicles (EVs), driven by environmental concerns and technological advancements.
Timileyin Opeyemi Akande, Oluwaseyi O Alabi, Ali Rizwan, Sunday A Ajagbe, Amos O Olaleye, Mathew O Adigun   +5 more
doaj   +1 more source

Structural Optimization Design of Dual Robot Gripper Unloading Device Based on Intelligent Optimization Algorithms and Generative Design. [PDF]

Sensors (Basel), 2023
Jia J, Sun X, Liu T, Tang J, Wang J, Hu X.   +5 more
europepmc   +1 more source