Results 131 to 140 of about 154,226 (313)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Journal of Asian Architecture and Building EngineeringThis paper proposes a method for floor plan designs that combines shape grammar with Building Information Modeling (BIM) technology to create plan module libraries by using the mass modular housing project in ShanLiChenJia village as an example.
Jiang Wang, Jiandong Zhou, Sheng Zhang
doaj +1 more source
Sensitive skin design: a generative approach [PDF]
, 2011 This paper presents a framework of study of an iterative evolution of a modular component designed in an attempt to simulate material constraints and motional response with the perspective to be multiplied into a dynamic system.
E. Kolovou
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
BuildingsAchieving robust environmental responsiveness in early stage architectural spatial layout design remains a critical challenge under the imperatives of global carbon neutrality and climate-adaptive building practice.
Rui Liu, Xiaofei Lu
doaj +1 more source
A generative design approach integrating climate and energy modeling with a design project in Navigli Milano [PDF]
LAUREA MAGISTRALEMilan has a long history of navigable canals that have played an important role in the city. This paper outlines the principles of both conventional and generative design approaches, conducting a thorough examination of the merits and ...
CAO, YAJUN
core
Inquiring the generative capacity of urban abstraction and mapping for first-semester basic design studio [PDF]
, 2023 The development of students’ critical and creative thinking skills is at the core of the first-semester basic design studio. Students’ perceptual experiences of their environment form the key references of abstraction in this beginning phase.
Yorgancıoğlu, Derya +2 more
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Evolving Memory in Gene Regulatory Networks for Artificial Growth
IEEE AccessUsing simple artificial evolution to assist in the design of complex engineering systems has a number of issues regarding diversity, scalability etc.
Colin Roitt +3 more
doaj +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source