Results 131 to 140 of about 10,007,622 (296)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
AI for Garden Design Visualization: Development and Validation of the GardenDiff Model
BuildingsThe rapid advancement of AI-driven generative design brings new opportunities, but its application in landscape garden design remains limited by two gaps: (1) semantic misalignment between generated images and the designer’s intent, and (2) low ...
Xiaolong Sun +5 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
DesignsIn recent years, Additive Manufacturing (AM) has transformed the development of new products, enabling more efficient, sustainable, and creative solutions across multiple sectors.
Beatriz M. Braga +5 more
doaj +1 more source
Probabilistic generative transformer language models for generative design of molecules. [PDF]
J Cheminform, 2023 Wei L, Fu N, Song Y, Wang Q, Hu J.
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Generative Design of Structured Materials for Controlled Frequency Responses. [PDF]
3D Print Addit Manuf, 2023 Yang W, Huang L, Singamneni S.
europepmc +1 more source
, 2006 Generative Components is the name given to a new kind of computer-aided-design software being pioneered by Bentley Microstation, and which is currently being beta-tested by leading international architectural practices such as Foster and Partners or Kohn
Martin, A. +3 more
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