Results 141 to 150 of about 133,835 (264)

Generative design of synthetic gene circuits for functional and evolutionary properties. [PDF]

NPJ Syst Biol Appl
Gallup O, Steel H.
europepmc   +1 more source

Generative design of 3D printed hands-free door handles for reduction of contagion risk in public buildings. [PDF]

Int J Interact Des Manuf, 2022
De Crescenzio F, Fantini M, Asllani E.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A. [PDF]

Brief Bioinform
Qian H, You P, Zeng L, Zhou J, Huang D, Li K, Tu S, Xu L.   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Evaluating BindCraft for Generative Design of High-Affinity Peptides. [PDF]

ACS Chem Biol
Filius M, Patsos T, Minnee H, Turco G, Chong HE, Liu J, Gnatzy M, Rooth RSM, Liu ACH, Ta RDT, Rijk IHA, Ziani S, Boxman FJ, Pomplun SJ.   +13 more
europepmc   +1 more source

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices. [PDF]

Adv Sci (Weinh), 2021
He Y, Abdi M, Trindade GF, Begines B, Dubern JF, Prina E, Hook AL, Choong GYH, Ledesma J, Tuck CJ, Rose FRAJ, Hague RJM, Roberts CJ, De Focatiis DSA, Ashcroft IA, Williams P, Irvine DJ, Alexander MR, Wildman RD.   +18 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Generative Design of 3D-Printed Biomimetic Interlocking Blocks Inspired by the Cellular 3D Puzzle Structure of the Walnut Shell. [PDF]

Biomimetics (Basel)
Efstathiadis A, Symeonidou I, Tsongas K, Tzimtzimis EK, Tzetzis D.   +4 more
europepmc   +1 more source

Deep generative design of porous organic cages via a variational autoencoder.

Digit Discov, 2023
Zhou J, Mroz A, Jelfs KE.
europepmc   +1 more source