Results 151 to 160 of about 133,835 (264)

3D printed plates based on generative design biomechanically outperform manual digital fitting and conventional systems printed in photopolymers in bridging mandibular bone defects of critical size in dogs. [PDF]

Front Vet Sci, 2023
Baumgartner D, Schramel JP, Kau S, Unger E, Oberoi G, Peham C, Eberspächer-Schweda M.   +6 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

MOFGPT: Generative Design of Metal-Organic Frameworks using Language Models. [PDF]

J Chem Inf Model
Badrinarayanan S, Magar R, Antony A, Meda RS, Barati Farimani A.   +4 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Generative design of singlet fission materials leveraging a fragment-oriented database. [PDF]

Chem Sci
Worakul T, Laplaza R, Blaskovits JT, Corminboeuf C.   +3 more
europepmc   +1 more source

Derivatization Design of Synthetically Accessible Space for Optimization: <i>In Silico</i> Synthesis vs Deep Generative Design. [PDF]

ACS Med Chem Lett, 2021
Makara GM, Kovács L, Szabó I, Pőcze G.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Generative design as a tool to analyse the uncertain loading regimes of intricate skeletal structures. [PDF]

J R Soc Interface
Racy JM, Boom B, Summers A.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Correction: Ma et al. Generative Design in Building Information Modelling (BIM): Approaches and Requirements. <i>Sensors</i> 2021, <i>21</i>, 5439. [PDF]

Sensors (Basel)
Ma W, Wang X, Wang J, Xiang X, Sun J.
europepmc   +1 more source