Results 151 to 160 of about 422,386 (278)

A Case Study of Applying Generative Design to Gear Wheels. [PDF]

Materials (Basel)
Virostko M, Maláková S, Kopas M, Mantič M, Kuľka J, Krenicky T, Lopot F, Petr K.   +7 more
europepmc   +1 more source

Generative design of 3D printed hands-free door handles for reduction of contagion risk in public buildings. [PDF]

Int J Interact Des Manuf, 2022
De Crescenzio F, Fantini M, Asllani E.
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A. [PDF]

Brief Bioinform
Qian H, You P, Zeng L, Zhou J, Huang D, Li K, Tu S, Xu L.   +7 more
europepmc   +1 more source

3D printed plates based on generative design biomechanically outperform manual digital fitting and conventional systems printed in photopolymers in bridging mandibular bone defects of critical size in dogs. [PDF]

Front Vet Sci, 2023
Baumgartner D, Schramel JP, Kau S, Unger E, Oberoi G, Peham C, Eberspächer-Schweda M.   +6 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Evaluating BindCraft for Generative Design of High-Affinity Peptides. [PDF]

ACS Chem Biol
Filius M, Patsos T, Minnee H, Turco G, Chong HE, Liu J, Gnatzy M, Rooth RSM, Liu ACH, Ta RDT, Rijk IHA, Ziani S, Boxman FJ, Pomplun SJ.   +13 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Generative Design of 3D-Printed Biomimetic Interlocking Blocks Inspired by the Cellular 3D Puzzle Structure of the Walnut Shell. [PDF]

Biomimetics (Basel)
Efstathiadis A, Symeonidou I, Tsongas K, Tzimtzimis EK, Tzetzis D.   +4 more
europepmc   +1 more source

Deep generative design of porous organic cages via a variational autoencoder.

Digit Discov, 2023
Zhou J, Mroz A, Jelfs KE.
europepmc   +1 more source