Results 171 to 180 of about 10,007,622 (296)

Generative Design Research Methods for Sustainability: Graduate Research and Design Interventions on Effective Use of Water

This paper presents a course model, Generative Design for Sustainability, that brings together Experience Chart (EC) guide as a user observation method and two generative research methods, namely Design for User Intention (DUI) and Experience Reflection ...
Dilruba, Oğur,, Çağla, Doğan,, Turhan, Senem,   +2 more
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Boron-assisted synthesis of compositionally complex amorphous oxides via short-range-order-constrained generative design. [PDF]

Sci Adv
Li H, Liu C, Guo Y, Luo X, Chen Y, Liu G, Li Y, Wang Z, Wu J, Zuo S, Luo Z, Peng C, Jiang Q, Li J, Ma C, Xie Z, Lv J, Ding Y, Zhang H, Li M, Wang Y, Li WL.   +21 more
europepmc   +1 more source

Deep generative design with 3D pharmacophoric constraints. [PDF]

Chem Sci, 2021
Imrie F, Hadfield TE, Bradley AR, Deane CM.   +3 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

A Case Study of Applying Generative Design to Gear Wheels. [PDF]

Materials (Basel)
Virostko M, Maláková S, Kopas M, Mantič M, Kuľka J, Krenicky T, Lopot F, Petr K.   +7 more
europepmc   +1 more source

Generative Design in Building Information Modelling (BIM): Approaches and Requirements. [PDF]

Sensors (Basel), 2021
Ma W, Wang X, Wang J, Xiang X, Sun J.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Generative design of synthetic gene circuits for functional and evolutionary properties. [PDF]

NPJ Syst Biol Appl
Gallup O, Steel H.
europepmc   +1 more source

Generative design of 3D printed hands-free door handles for reduction of contagion risk in public buildings. [PDF]

Int J Interact Des Manuf, 2022
De Crescenzio F, Fantini M, Asllani E.
europepmc   +1 more source