Results 121 to 130 of about 422,386 (278)

Perfect prosthetic heart valve: generative design with machine learning, modeling, and optimization. [PDF]

Front Bioeng Biotechnol, 2023
Danilov VV, Klyshnikov KY, Onishenko PS, Proutski A, Gankin Y, Melgani F, Ovcharenko EA.   +6 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The Use of Generative AI to Support Inclusivity and Design Deliberation for Online Instruction

Online Learning
Generative AI presents significant opportunities for instructional designers to revolutionize content creation and personalization in online learning environments.
Jill Stefaniak, Stephanie Moore
doaj   +1 more source

Open Macromolecular Genome: Generative Design of Synthetically Accessible Polymers. [PDF]

ACS Polym Au, 2023
Kim S, Schroeder CM, Jackson NE.
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A New Zero Waste Design for a Manufacturing Approach for Direct-Drive Wind Turbine Electrical Generator Structural Components

Machines
An integrated structural optimization strategy was produced in this study for direct-drive electrical generator structures of offshore wind turbines, implementing a design for an additive manufacturing approach, and using generative design techniques ...
Daniel Gonzalez-Delgado, Pablo Jaen-Sola, Erkan Oterkus   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

3D constructing: Exploring the potential of 3D concrete and clay printing with generative design for architectural innovation

Informes de la Construccion
The architectural and construction sectors are experiencing a transformative shift with the advent of 3D constructing. This research delves into the potential of 3D printing technologies when combined with generative design principles to reshape ...
Javier Alonso Madrid, Guillermo Sotorrio, Nils Olsson, José Antonio Tenorio   +3 more
doaj   +1 more source

Structural Optimization Design of Dual Robot Gripper Unloading Device Based on Intelligent Optimization Algorithms and Generative Design. [PDF]

Sensors (Basel), 2023
Jia J, Sun X, Liu T, Tang J, Wang J, Hu X.   +5 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source