Results 121 to 130 of about 10,007,622 (296)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Methodological Framework for Semiconductor Fab Design Using Dynamo-Based Generative Design

Applied Sciences
The rapid growth of the semiconductor industry has created a bottleneck in which traditional manual methods for designing fabrication plants (fabs) cannot keep pace with their high complexity and short technological lifecycles.
Yeongyu Hwang, WonSeok Choi, Minhyuk Jung, Wonho Cho, Jaewook Lee   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Generative Design in Urban Planning with Regard to Local Zoning Regulations: A BIM Case Study

Urban Science
The development of Building Information Modeling (BIM) and Generative Design (GD) methods supported by artificial intelligence opens up new possibilities in the field of urban planning analyses and the verification of land-use compliance with local ...
Andrzej Szymon Borkowski, Filip Pawlikowski, Anna Ptaszek, Patrycja Raczkowska, Wiktoria Winiarska, Natalia Wyrzykowska   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Generative generation design

, 2017
Today it is increasingly essential to fully understand the potential of the software, now able to let us hire more awareness in the control of the project, but especially in the potential of new forms of development. Evolved codes and programming languages are already available and, as well as giving many ideational possibilities, place their ...
openaire   +1 more source

Creative combinational design through generative AI in different dimensional representations: an exploration

Although generative AI models are increasingly integrated into creative work, there is limited evidence on how dimensional representations of generative AI—text, image, and 3D—impact the creative process.
Han, Ji, Chen, Liuqing, Childs, Peter, Zhao, Xiaoyang, Wang, Boheng, Yin, Yuan   +5 more
core   +1 more source

Generative design and additive manufacturing in assistive devices : educational strategies for human-centred solutions [PDF]

This paper explores how Generative Design (GD), Additive Manufacturing (AM), and multi-stakeholder design approaches can inform engineering education for assistive technology innovation.
Patiniott, Nicholas, Farrugia, Philip, Mercieca, Adrian, International Conference on Engineering and Product Design Education (E&PDE 2025), Borg, Jonathan C.   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source