Results 91 to 100 of about 71,961 (266)
SECONDGRAM: Self-conditioned diffusion with gradient manipulation for longitudinal MRI imputation
PatternsSummary: While individual MRI snapshots provide valuable insights, the longitudinal progression in repeated MRIs often holds more significant diagnostic and prognostic value.
Brandon Theodorou +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular relaxation by reverse diffusion with time step prediction
Machine Learning: Science and TechnologyMolecular relaxation, finding the equilibrium state of a non-equilibrium structure, is an essential component of computational chemistry to understand reactivity.
Khaled Kahouli +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Integrating Pretrained Encoders for Generalized Face Frontalization
IEEE AccessIn the field of face frontalization, the model obtained by training on a particular dataset often underperforms on other datasets. This paper presents the Pre-trained Feature Transformation GAN (PFT-GAN), which is designed to fully utilize diverse facial
Wonyoung Choi +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IEEE Open Journal of the Computer SocietyDriver digital twins (DTs) provide a structured mechanism for capturing individualized behavioral characteristics in connected vehicle systems. However, most existing approaches rely on centralized data access and discriminative learning pipelines ...
Ajmal Khan +7 more
doaj +1 more source
A Model for General Intelligence
CoRR, 2018 7 pages; distribution statement ...
openaire +2 more sources