Results 211 to 220 of about 425,706 (317)

Visible through touch: open-source 3D-printed tools for inclusive microbiology education. [PDF]

Access Microbiol
Price CL, Seeley A, Pincott H, Morse DJ, Harris LG, Noble JG.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Capacitor Activated Self-Excitation System of Synchronous Generator

In this paper the self-excitation system of synchronous generator based on capacitor discharge through excitation winding is described. The system comprises three-phase synchronous generator with connected in star scheme stator winding with neutral wire ...
Zaļeskis, Genadijs, Raņķis, Ivars
core  

Generative AI-Assisted Indication of Anatomical Landmarks to Enhance Safety under Intraoperative Bleeding in Laparoscopic Gastrectomy for Gastric Cancer. [PDF]

Ann Surg Open
Fujishima R, Matsunobu Y, Etoh T, Aoyama Y, Hasegawa T, Shitomi Y, Ninomiya S, Ueda Y, Hanada R, Tokuyasu T, Inomata M.   +10 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Semigroup-theoretic analysis of supply-chain disruptions and resilience. [PDF]

PLoS One
Opue JA, Sampson MI, Tom OJ, Okorie UE.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Directly-Driven Inductor Wind Generator of Ring Construction

A design of the inductor generator for 12-kW wind plants is considered, with the rotational speed of 100 min-1, directly driven from a wind turbine without a step-up multiplier.
Pugačevs, Vladislavs, Manonovs, Muhabats, Ribickis, Leonīds, Levins, Nikolajs   +3 more
core  

Lead-to-Port Reversal Mimicking Loss of Cardiac Resynchronization Therapy After CRT-D Generator Replacement. [PDF]

JACC Case Rep
Sahin AT, Kesriklioglu S, Sertdemir AL, Gul EE.   +3 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source