Results 231 to 240 of about 1,557,809 (346)

Compact neutron generators for the calibration of low background experiments

, 2019
А.С. Чепурнов, M. Gromov, V. Yu. Ionidi, A. A. Kaplii, MA Kirsanov, A. A. Klenin, Dmitry Kolesnikov, A. Kubankin, A Yu Maslenkina, A. Oleinik, D. Selivanova, A. Shchagin   +11 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improving Population Pharmacokinetic Modelling with Artificial Patients using Generative Artificial Intelligence. [PDF]

Pharmacol Res Perspect
Schöning V, Hammann F.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Anesthetic Management of Patients for Vagal Nerve Stimulator Placement: A Narrative Review. [PDF]

Neuropsychiatr Dis Treat
Henderson NA, Anwar AI, Duet SJ, Rayes Elmalakh S, Shetty V, Shekoohi S, Ahmadzadeh S.   +6 more
europepmc   +1 more source

A Data Acquisition System for Evapotranspiration Measurement in Remote Fields Using Mobile Telephone and Small DC Generator

, 1997
Masatoshi Aoki, Takashi Machimura, Yoshiaki Hideshima, Norio OBASE, Michihide WADA, Takashi Satoh   +5 more
openalex   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Experimental optimization of disc-type generators for low-velocity hydrokinetic energy harvesting. [PDF]

Sci Rep
Wang H, He M, Li G, Sun X, Xi P, Shao N.
europepmc   +1 more source

4. THE X-RAY HIGH VOLTAGE GENERATOR OF INVERTER TYPE FOR ANGIOGRAPHY AND CINE RADIOGRAPHY

, 1990
MITUO KATUMATA
openalex   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source