Results 91 to 100 of about 721,814 (289)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Effects of alcohol-gasoline blends on exhaust and noise emissions in small scaled generators
Metalurgija, 2010 In this study, the effect of methanol or butanol addition to gasoline on exhaust emissions and noise level has been experimentally investigated. Results showed that the concentrations of CO and NOx emissions were decreased depending on the higher alcohol
A. Yasar
doaj
СХЕМИ ЗАМІЩЕННЯЕЛЕКТРИЧНИХ МАШИН
Elektrotehnìka ta Elektroenergetika, 2013 Встановлено, що для електричних машин будь-якого типу можуть бути складені схеми заміщення аналогічні схемам заміщення двополюсника. Тим самим досягнута уніфікація їх дослідження у відповідності з принципами системності та прийнятності.
A. V. Кitayev +2 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Pediatric Nephrology, 2017 Immunosuppressive drugs for solid organ transplantation are critical dose drugs with a narrow therapeutic index. Many of the most commonly used innovator drugs are off patent and have been replicated by generic counterparts, often at substantial cost-savings to the patient.
Mara Medeiros +4 more
openaire +5 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Advances in Electrical and Electronic Engineering, 2018 The paper is about the design and prototyping of directly driven outer rotor permanent magnet generator for small scale wind turbine. In the paper, the initial design of the generator is given.
Toomas Vaimann +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A Proposal of a Novel Method for Generating Discrete Analog Uniform Noise
Advances in Electrical and Computer Engineering, 2018 This paper presents a proposal of a new way to generate analog noise, discrete in time, with uniform probability density function. Instead of the usual way of generating discrete analog uniform noise using a uniform pseudorandom number generator and a ...
PEJIC, D. +5 more
doaj +1 more source