Results 151 to 160 of about 2,442,464 (298)
Reshaping Australian drug policy: the dilemmas of generic medicines policy
, 2007 Reshaping Australian drug policy: the dilemmas of generic medicines ...
Hans Lofgren (13050564)
core
Advanced Science, EarlyView.The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng +10 more
wiley +1 more source
Advanced Science, EarlyView.We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong +11 more
wiley +1 more source
Advanced Science, EarlyView.In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang +20 more
wiley +1 more source
Generic drugs use during the COVID-19 pandemic among Lebanese patients using psychotropics: An opportunity for generic drug promotion. [PDF]
J Generic Med, 2023 Hatem G +4 more
europepmc +1 more source
The impact of generic reference pricing interventions in the statin market [PDF]
The objective of this study was to evaluate the intended and unintended impact on pharmaceutical use and sales of three public financing reforms applied to the prescription of statins: a Spanish generic reference pricing (RP) system for lovastatin and ...
Jaume Puig
core
Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair
Advanced Science, EarlyView.A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng +8 more
wiley +1 more source
Reimagining Bioequivalence for the Era of Complex Drug Products: A Quantitative Framework for Generic Drug Development. [PDF]
Clin Transl SciDunn A, Lee S, Gobburu JVS.
europepmc +1 more source
Advanced Science, EarlyView.Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong +9 more
wiley +1 more source
Model-Integrated Bioequivalence (MIBE) in Generic Drug Research: Can We Ease the Bioequivalence Burden? [PDF]
PharmaceuticsKollipara S +3 more
europepmc +1 more source