Results 191 to 200 of about 2,442,464 (298)

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolimus. [PDF]

Pharmaceutics
Karakitsios E, Angelerou MF, Kapralos I, Tsakiridou G, Kalantzi L, Dokoumetzidis A.   +5 more
europepmc   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Frequency of First Generic Drug Approvals With "Skinny Labels" in the United States.

JAMA Intern Med, 2021
Walsh BS, Sarpatwari A, Rome BN, Kesselheim AS.   +3 more
europepmc   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Association of California's Prescription Drug Coupon Ban With Generic Drug Use.

JAMA, 2021
Rome BN, Gagne JJ, Kesselheim AS.
europepmc   +1 more source

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

Advanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye   +12 more
wiley   +1 more source

Which factor reduces pharmaceutical expenditure, number of entrants or price variance? Updated generic drug markets in South Korea. [PDF]

Health Econ Rev
Son KB.
europepmc   +1 more source

Snapshot Spatiotemporal‐Spectral Imaging Enabled by Joint Photonic Encoding

Advanced Science, EarlyView.
Spectra4D enables snapshot spatiotemporal‐spectral imaging by combining high‐speed DMD temporal modulation with CMOS‐integrated Fabry‐Pérot spectral encoding. From a single 2D measurement, a dual‐mask‐guided reconstruction network recovers multiple time‐resolved hyperspectral frames, enabling high‐fidelity observation of rapidly evolving spatial ...
Chunyu Chen, Junren Wen, Hao Sha, Chenying Yang, Ziyang Chen, Xiaochen Feng, Taiqin Chen, Wenzhen Zou, Xiangyu Chen, Xiangyang Ji, Guojun Liu, Yongbing Zhang   +11 more
wiley   +1 more source

A mesoporous superparamagnetic iron oxide nanoparticle as a generic drug delivery system for tumor ferroptosis therapy. [PDF]

J Nanobiotechnology
Yang J, Xiong W, Huang L, Li Z, Fan Q, Hu F, Duan X, Fan J, Li B, Feng J, Xu Y, Chen X, Shen Z.   +12 more
europepmc   +1 more source