Results 61 to 70 of about 2,442,464 (298)

Uncertainty in the Generic Versus Brand Name Prescription Decision [PDF]

This paper analyzes the impact of uncertainty concerning product quality of generic drugs on the substitution behavior of prescribing physicians. It is shown that uncertainty about the generic drug quality gives the physician a value of waiting for more ...
Hellström, Jörgen, Rudholm, Niklas
core  

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Evaluation of orally disintegrating tablets: regulatory pathways, administration practices and harmonization of bioequivalence study design

AAPS Open
Orally disintegrating tablets (ODTs) are a solid oral dosage form designed to rapidly disintegrate in the mouth without the need for water, improving patient compliance—particularly among pediatric, geriatric, and dysphagic populations.
Shapali Bagde, Xinyuan Xi, Heather Boyce, Myong-Jin Kim   +3 more
doaj   +1 more source

Effects of gut microbiota dysbiosis on the metabolism and pharmacokinetics of losartan in rats: from endogenous to ceftriaxone-induced dysbiosis

Frontiers in Microbiology
IntroductionGut microbiota plays a key role in drug metabolism. While gut microbiota dysbiosis is known to contribute to hypertension pathogenesis, its impact on drug metabolism remains poorly considered.
Jiaxuan Xia, Jiaxuan Xia, Jiaxuan Xia, Yibao Jin, Yanjun Hong, Yuefeng Zhang, Meifang Li, Houshuang Huang, Xu Cai, Dan Li, Bing Wang, Zhiyong Xie   +11 more
doaj   +1 more source

Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy

Frontiers in Immunology, 2018
Concanavalin A-induced autoimmune hepatitis is a well-established experimental model for immune-mediated liver injury. It has been widely used in the therapeutic studies of immune hepatitis. The in-depth analysis of dysregulated proteins from comparative
Qin Feng, Qin Feng, Jingchun Yao, Ge Zhou, Wenkai Xia, Jingang Lyu, Xin Li, Tao Zhao, Guimin Zhang, Guimin Zhang, Ningwei Zhao, Ningwei Zhao, Jie Yang, Jie Yang   +13 more
doaj   +1 more source

Generic Utilization Rates, Real Pharmaceutical Prices, and Research and Development Expenditures [PDF]

Generic utilization rates have risen substantially since the enactment of The Drug Price Competition and Patent Term Restoration Act (Hatch-Waxman) in 1984.
Joseph P. Cook, John A. Vernon, Graeme Hunter   +2 more
core  

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Biocatalytic kinetic resolution for efficient and enantioselective synthesis of δ-haloalcohols and tetrahydrofurans

Communications Chemistry
Expanding biocatalytic reactions to access previously inaccessible chemical transformations is of significant demand. Halohydrin dehalogenases represent a class of remarkably versatile biocatalysts that have been successfully explored in the asymmetric ...
Yuan-Fei Wang, Xia Hua, Zhang-Yang Wang, Xiao Jin, Hui-Hui Wang, Yong-Zheng Chen, Nan-Wei Wan   +6 more
doaj   +1 more source

Effects of 'Authorized-Generics' on Canadian Drug Prices [PDF]

This paper examines how the use of ‘authorized-generics’ (AGs) influences Canadian prescription drug prices. An authorized-generic is the actual brand name drug product, manufactured by the brand firm, but sold as a generic by a licensee or subsidiary of
Paul Grootendorst
core  

Parameter Investigation for Stamp Manufacturing of Complex 3D Geometries Using Nanoimprint Lithography

Advanced Materials Technologies, EarlyView.
Nanoimprint lithography can replicate complex 3D microstructures with undercuts using single‐layer polymer stamps of different elasticities. By combining experiments and simulations, T‐shaped geometries and suitable undercut radii were identified that minimize stress and defects during demolding.
Christos Julianos Karapatzakis, Selina Burkert, Cordelia Friederike Wittemann, Andreas Heinrich   +3 more
wiley   +1 more source