The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
What a Loaded Generalization: Generics and Social Cognition
, 2015 Daniel Wodak, S. Leslie, M. Rhodes
semanticscholar +1 more source
MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source
Comparison of the review models and regulatory timelines of seven countries participating in the ECOWAS-MRH initiative: identifying opportunities for improvement. [PDF]
Front Med (Lausanne)Owusu-Asante M +16 more
europepmc +1 more source
Learned Conformational Space and Pharmacophore Into Molecular Foundational Model
Advanced Science, EarlyView.The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang +8 more
wiley +1 more source
Economic evaluation of generic inhalational bronchodilators from the Jan-Aushadi scheme versus branded alternatives. [PDF]
Cost Eff Resour AllocJames J +3 more
europepmc +1 more source
Advanced Science, EarlyView.A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang +12 more
wiley +1 more source
Determinants of the generic's prescription among general practitioners in Casablanca, Morocco: A cross-sectional study. [PDF]
J Family Med Prim CareTraore B, Zoukal S, Hassoune S.
europepmc +1 more source
Advanced Science, EarlyView.By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang +27 more
wiley +1 more source