Results 241 to 250 of about 801,477 (317)

Deciphering the pangenome of the shellfish pathogen <i>Vibrio europaeus</i>: evolutionary history and functional impact of core and accessory genes in aquaculture. [PDF]

Microb Genom
Rodriguez S, Rey-Varela D, Blanco-Hortas A, Martinez C, Martínez P, Travers MA, Barja JL, Dubert J.   +7 more
europepmc   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Urban greenspaces harbour distinct plasmid communities enriched in heavy metal resistance and competitive traits in arid soils. [PDF]

Microbiology (Reading)
Touceda-Suárez M, Ponsero AJ, Barberán A.   +2 more
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

A newly discovered <i>Aerococcus urinae</i> mediates transfer of the pCF10 plasmid via SPI-WT regulation. [PDF]

Front Microbiol
Zhang M, Yang X, Li R, Qian J, Hao R, Xu L, He Q, Shen Z, Wang J, Zhu Y, Qiu Z.   +10 more
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Development of a multiplex recombinase polymerase amplification combined with a DNA strip for the rapid detection of <i>Enterococcus faecium</i>, <i>Enterococcus faecalis</i>, and vancomycin resistance genes. [PDF]

PeerJ
Thaweesub P, Lulitanond A, Chanawong A, Thitiwatrueangrut S, Khlaichanthong P, Tippayawat P, Wongwattanakul M, Sripichai O, Srisrattakarn A.   +8 more
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Conservation Tillage-Mediated Rhizosphere Microbial Community Remodeling Drives Soil Organic Carbon Accumulation and Nitrogen and Phosphorus Transformation in Farmland. [PDF]

Microorganisms
Zhao H, Cheng M, Wei S, Shi G, Fang J, Shi H, Liu Q, Qu Y, Zhang W, Luo F, Wang Y, Lu Z, Zhang D, Zhao X.   +13 more
europepmc   +1 more source