Results 51 to 60 of about 801,477 (317)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Population-associated differences between the phase variable LPS biosynthetic genes of Helicobacter pylori

, 2006
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Salaün, L, Saunders Nigel J, Salaün Laurence, Saunders, Nigel, Saunders, NJ, Laurence Salaün, Nigel J Saunders, Saunders, Nigel J., Saunders, Nigel J, Salaün, Laurence   +9 more
core   +1 more source

Polymicrobial airway bacterial communities in adult bronchiectasis patients [PDF]

, 2014
Background: Chronic airway infection contributes to the underlying pathogenesis of non-cystic fibrosis bronchiectasis (NCFBr). In contrast to other chronic airway infections, associated with COPD and CF bronchiectasis, where polymicrobial communities ...
Christopher J Stewart, Smith, Darren L., Jary, Hannah, Andrew Nelson, Perry, J. D. (John), Nelson, Andrew, Stewart, Christopher, Smith, Darren, Anthony De Soyza, Stephen P Cummings, Perry, A, John D Perry, Clare Lanyon, Purcell, Paul, Lanyon, Clare, Hannah Jary, Darren L Smith, Paul Purcell, de Soyza, Anthony, Perry, Audrey, Cummings, Stephen, Perry, John, Audrey Perry   +22 more
core   +1 more source

Bacterial gene expression at low temperatures

Extremophiles, 2012
Under suboptimal environmental conditions such as low temperatures, many bacteria have an extended lag phase, altered cell structures, and composition such as a less fluid (more rigid) and leaky cytoplasmic membrane. As a result, cells may die, enter into a starvation mode of metabolism or a physiologically viable but non-culturable (VBNC) state.
Trevors, J.T., Bej, A.K., Mojib, N., van Elsas, J.D., van Overbeek, L.S.   +4 more
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness

Scientific Reports, 2017
Lower respiratory tract infection (LRTI) commonly causes hospitalization in adults. Because bacterial diagnostic tests are not accurate, antibiotics are frequently prescribed. Peripheral blood gene expression to identify subjects with bacterial infection
Soumyaroop Bhattacharya, Alex F. Rosenberg, Derick R. Peterson, Katherine Grzesik, Andrea M. Baran, John M. Ashton, Steven R. Gill, Anthony M. Corbett, Jeanne Holden-Wiltse, David J. Topham, Edward E. Walsh, Thomas J. Mariani, Ann R. Falsey   +12 more
doaj   +1 more source

Bacterial infection in scarring trachoma. [PDF]

, 2010
PURPOSE: To assess whether non-chlamydial bacterial infection is associated with trachomatous scarring in adults. METHODS: This was a case-control study of 360 cases with trachomatous scarring but without trichiasis, and 360 controls without scarring ...
Chevallier, Caroline, Afwamba, Isaac A, David C. W. Mabey, Weiss, Helen A, Isaac A. Afwamba, Burton, Matthew J, Helen A. Weiss, Patrick Massae, Bailey, Robin L, Hu, Victor H, Jecinta J. Onyango, Matthew J. Burton, Onyango, Jecinta J, Caroline Chevallier, Massae, Patrick, Mabey, David CW, Victor H. Hu, Robin L. Bailey   +17 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Silicon dioxide nanoparticles have contrasting effects on the temporal dynamics of sulfonamide and β-lactam resistance genes in soils amended with antibiotics

Environmental Research Letters, 2020
Nanoparticles (NPs) and antibiotic resistant genes (ARGs), as emerging environmental contaminants, have been reported to be accumulated in the soil environment.
Xiujuan Zhang, Junjian Li, Dale Li, Hong Zhang, Hangwei Hu   +4 more
doaj   +1 more source