Results 71 to 80 of about 801,477 (317)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum

, 2006
In many plant and animal bacterial pathogens, the Type III secretion system (TTSS) that directly translocates effector proteins into the eukaryotic host cells is essential for the development of disease.
Christian Boucher, Valls Marc, Valls i Matheu, Marc, Marc Valls, Boucher, Christian, Genin Stéphane, Genin, S., Boucher Christian, Stéphane Genin   +8 more
core   +1 more source

Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization inClostridium kluyveri [PDF]

, 2009
It has been suggested that ethanol metabolism in the strict anaerobe Clostridium kluyveri occurs within a metabolosome, a subcellular proteinaceous bacterial microcompartment. Two bacterial microcompartment shell proteins [EtuA (ethanol utilization shell
Seyedarabi, Arefeh, Warren, Martin J, Warren, Martin J., Pickersgill, Richard W, Parsons, Joshua B., Heldt, Dana, Parsons, Joshua B, Ladikis, Dimitrios, Frank, Stefanie, Pickersgill, Richard W., Ladakis, Dimitrios   +10 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Chitosan-based structures for targeting bacterial biofilm-associated genes

Carbohydrate Polymer Technologies and Applications
Biofilms are a common lifestyle, in which bacteria grow as multicellular communities. The negative consequences of biofilms are well known. The targeted suppression of certain genes is a promising approach for combating biofilms. Chitosan (CS) has become
Shima Afrasiabi
doaj   +1 more source

Analysis of differentially expressed genes in bacterial and fungal keratitis

Indian Journal of Ophthalmology, 2020
Purpose: This study was aimed at identifying differentially expressed genes (DEGs) in bacterial and fungal keratitis. The candidate genes can be selected and quantified to distinguish between causative agents of infectious keratitis to improve ...
Rui Tian, He Zou, Lufei Wang, Lu Liu, Meijiao Song, Hui Zhang   +5 more
doaj   +1 more source

Recovery of the Structure and Function of the Pig Manure Bacterial Community after Enrofloxacin Exposure

Microbiology Spectrum, 2022
At present, growth-promoting antibiotics are banned in the pig industry in many countries, but therapeutic antibiotics can still be used normally. However, the effect of therapeutic antibiotics on the structure and function of the intestinal bacterial ...
Tao Chen, Gaomiao Xie, Jiandui Mi, Xin Wen, Zhen Cao, Baohua Ma, Yongde Zou, Na Zhang, Yan Wang, Xindi Liao, Yinbao Wu   +10 more
doaj   +1 more source

Steps toward broad-spectrum therapeutics : discovering virulence-associated genes present in diverse human pathogens [PDF]

, 2009
© 2009 Stubben et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Karlyshev, Andrey V., Gans, Jason D, Oyston, Petra C. F., Ford, Donna C., Gans, Jason D., Wolinsky Murray, Titball, Richard W., Cooper, Ian A, Karlyshev, Andrey, Wren, Brendan W, Cooper Ian A, Duffield Melanie L, Duffield, Melanie, Ford Donna C, Lingard, Bryan, Ford, Donna C, Stubben, Chris J., Wren, Brendan W., Oyston, Petra CF, Karlyshev, Andrey V, Titball, Rick W, Lingard, Brian, Duffield, Melanie L, Karlyshev Andrey V, Gans Jason D, Oyston Petra CF, Song, Jian, Stubben, Chris J, Oyston, Petra C F, Titball Rick W, de Rochefort Anna, Stubben Chris J, Wren Brendan W, Lingard Bryan, Wolinsky, Murray, de Rochefort, Anna, Cooper, Ian A., Song Jian   +37 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bacteria under SOS evolve anticancer phenotypes

Infectious Agents and Cancer, 2010
Background The anticancer drugs, such as DNA replication inhibitors, stimulate bacterial adhesion and induce the bacterial SOS response. As a variety of bacterial mutants can be generated during SOS, novel phenotypes are likely to be selected under the ...
Weitao Tao, Dallo Shatha F
doaj   +1 more source