Results 71 to 80 of about 3,341,597 (311)

Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization inClostridium kluyveri [PDF]

, 2009
It has been suggested that ethanol metabolism in the strict anaerobe Clostridium kluyveri occurs within a metabolosome, a subcellular proteinaceous bacterial microcompartment. Two bacterial microcompartment shell proteins [EtuA (ethanol utilization shell
Seyedarabi, Arefeh, Warren, Martin J, Warren, Martin J., Pickersgill, Richard W, Parsons, Joshua B., Heldt, Dana, Parsons, Joshua B, Ladikis, Dimitrios, Frank, Stefanie, Pickersgill, Richard W., Ladakis, Dimitrios   +10 more
core   +1 more source

Dna Supercoiling and Bacterial Gene Expression [PDF]

Science Progress, 2006
DNA in bacterial cells is maintained in a negatively supercoiled state. This contributes to the organization of the bacterial nucleoid and also influences the global gene expression pattern in the cell through modulatory effects on transcription.
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]

, 2011
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Kroll J. Simon, J. Simon Kroll, Kroll J.S., Martin L. Hibberd, Wong, Hazel En En, Martin L Hibberd, Hazel En En Wong, J Simon Kroll, Hibberd Martin L., Hibberd M.L., Wong H.E.E., Langford, PR, Wong Hazel En En, Li, Ming-Shi, Kroll, J Simon, Li, M-S, Hibberd, ML, Langford Paul R., Paul R. Langford, Li Ming-Shi, Ming-Shi Li, Paul R Langford, Li M.-S., Langford P.R., Wong, EEH, Langford, Paul R, Hibberd, Martin L, Kroll, JS   +27 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Bacterial gene expression at low temperatures

Extremophiles, 2012
Under suboptimal environmental conditions such as low temperatures, many bacteria have an extended lag phase, altered cell structures, and composition such as a less fluid (more rigid) and leaky cytoplasmic membrane. As a result, cells may die, enter into a starvation mode of metabolism or a physiologically viable but non-culturable (VBNC) state.
Trevors, J.T., Bej, A.K., Mojib, N., van Elsas, J.D., van Overbeek, L.S.   +4 more
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bacterial infection in scarring trachoma. [PDF]

, 2010
PURPOSE: To assess whether non-chlamydial bacterial infection is associated with trachomatous scarring in adults. METHODS: This was a case-control study of 360 cases with trachomatous scarring but without trichiasis, and 360 controls without scarring ...
Chevallier, Caroline, Afwamba, Isaac A, David C. W. Mabey, Weiss, Helen A, Isaac A. Afwamba, Burton, Matthew J, Helen A. Weiss, Patrick Massae, Bailey, Robin L, Hu, Victor H, Jecinta J. Onyango, Matthew J. Burton, Onyango, Jecinta J, Caroline Chevallier, Massae, Patrick, Mabey, David CW, Victor H. Hu, Robin L. Bailey   +17 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source