Results 91 to 100 of about 3,158,601 (308)
Chitosan-based structures for targeting bacterial biofilm-associated genes
Carbohydrate Polymer Technologies and ApplicationsBiofilms are a common lifestyle, in which bacteria grow as multicellular communities. The negative consequences of biofilms are well known. The targeted suppression of certain genes is a promising approach for combating biofilms. Chitosan (CS) has become
Shima Afrasiabi
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Environmental Research Letters, 2020 Nanoparticles (NPs) and antibiotic resistant genes (ARGs), as emerging environmental contaminants, have been reported to be accumulated in the soil environment.
Xiujuan Zhang +4 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Targeting bacterial biofilm-related genes with nanoparticle-based strategies
Frontiers in MicrobiologyPersistent infection caused by biofilm is an urgent in medicine that should be tackled by new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns of the persistent infection due to biofilm ...
Shima Afrasiabi, Alireza Partoazar
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Analysis of differentially expressed genes in bacterial and fungal keratitis
Indian Journal of Ophthalmology, 2020 Purpose: This study was aimed at identifying differentially expressed genes (DEGs) in bacterial and fungal keratitis. The candidate genes can be selected and quantified to distinguish between causative agents of infectious keratitis to improve ...
Rui Tian +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in Microbiology, 2020 The rise of antibiotic resistance is not only a challenge for human and animal health treatments, but is also posing the risk of spreading among bacterial populations in foodstuffs.
Nicolas Helsens +9 more
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Molecular Marker Detection and Analysis of Resistance to Bacterial Blight in 72 Rice Germplasms
Guangdong nongye kexue【Objective】In order to address the challenges posed by bacterial blight to the safety of rice production and to clarify the status of bacterial blight resistance genes in 72 rice germplasm materials.【Method】The total DNA of 72 rice germplasm materials ...
Ying HE +5 more
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