Results 111 to 120 of about 3,341,597 (311)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Cultivation-Independent Screening Revealed Hot Spots of IncP-1, IncP-7 and IncP-9 Plasmid Occurrence in Different Environmental Habitats [PDF]

, 2014
Dealtry S, Ding G-C, Weichelt V, et al. Cultivation-Independent Screening Revealed Hot Spots of IncP-1, IncP-7 and IncP-9 Plasmid Occurrence in Different Environmental Habitats. PLoS ONE.
Thomas Christopher, Carla Martini, Maria, Gaze, William Hugo,, Sipkema Detmer, Sara Sjöling (462200), Papa, M.F., Del, Smalla, K., Vincent Dunon, Elizabeth Margaret Helen Wellington (226811), María Florencia Del Papa (526836), Heuer Holger, Andreas Schlüter (201339), Gaze William Hugo, Dunon Vincent, Martini, María Carla,, Dunon, V., Dealtry Simone, Weichelt, V., Antonio Lagares (526837), Smalla, Kornelia,, Springael, D., Sjöling, Sara,, Antonio Lagares, Schluter, A., Sjoiling, Sara, William Hugo Gaze, Sjöling Sara, Gaze, W.H., Jan Dirk van Elsas, María Florencia Del Papa, Jan Dirk van Elsas (108387), María Carla Martini (526835), Detmer Sipkema, Elizabeth Margaret Helen Wellington, Weichelt Viola, Dealtry, Simone, Dirk Springael, Elsas, J.D., van Elsas Jan Dirk, Papa, María Florencia Del,, Springael, Dirk, Smalla Kornelia, Florencia Del Papa, Maria, Sjoling, S., Dealtry, Simone,, van Elsas, Jan Dirk, Heuer, Holger,, Gaze, William H., Thomas, Christopher,, Amos Gregory Charles Auton, Springael, Dirk,, Smalla, Kornelia, Elsas, J. D. van, Andreas, Schlüter, Detmer Sipkema (526839), Wellington, E.M.H., Papa, María Florencia Del, Weichelt, Viola, Ding Guo-Chun, Ding, Guo-Chun,, Christopher Thomas (502803), Wellington, E. M. H., Heuer, H., Sjoling, Sara, Gregory Charles Auton Amos (526838), Weichelt, Viola,, Wellington, Elizabeth Margaret Helen,, Kornelia Smalla, Ding, G.C., Schlüter, Andreas, Dunon, Vincent,, Simone Dealtry (526833), Sipkema, D., Viola Weichelt (526834), Holger Heuer, Wellington, Elizabeth Margaret Helen, Thomas, Christopher M., Thomas, C., Thomas, Christopher, Sara Sjöling, Guo-Chun Ding (392270), Andreas Schlüter, Schlüter, Andreas ; https://orcid.org/, Heuer, Holger, Elsas, Jan Dirk van, Ding, Guo Chun, Schlüter Andreas, Martini María Carla, Dunon, Vincent, Dirk Springael (526840), Springael Dirk, Sipkema, Detmer,, Martini, M.C., Guo-Chun Ding, Amos, Gregory C. A., María Carla Martini, William Hugo Gaze (226795), Ding, Guo-Chun, Amos, Gregory Charles Auton,, Sipkema, Detmer, Martini, María Carla, van Elsas, Jan Dirk,, Vincent Dunon (179030), Schlüter, Andreas,, Lagares, A., Viola Weichelt, Kornelia Smalla (130483), Lagares Antonio, Wellington Elizabeth Margaret Helen, Auton Amos, Gregory Charles, Amos, G.C.A., Lagares, Antonio,, Holger Heuer (392271), Gaze, William Hugo, Dealtry, S., Thomas, Christopher; id_orcid, Papa María Florencia Del, Amos, Gregory Charles Auton, Del Papa, María Florencia, Gregory Charles Auton Amos, Christopher Thomas, Simone Dealtry, Lagares, Antonio   +122 more
core   +1 more source

Transcriptome sequencing and expression analysis in peanut reveal the potential mechanism response to Ralstonia solanacearum infection

BMC Plant Biology
Background Bacterial wilt caused by Ralstonia solanacearum severely affects peanut (Arachis hypogaea L.) yields. The breeding of resistant cultivars is an efficient means of controlling plant diseases.
Xiao Wang, Feiyan Qi, Ziqi Sun, Hongfei Liu, Yue Wu, Xiaohui Wu, Jing Xu, Hua Liu, Li Qin, Zhenyu Wang, Suling Sang, Wenzhao Dong, Bingyan Huang, Zheng Zheng, Xinyou Zhang   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions [PDF]

, 2013
Background Amoebae and bacteria interact within predator-prey and host-pathogen relationships, but the general response of amoeba to bacteria is not well understood.
Juneja, Kavina, Miranda, Edward Roshan, Zupan, Blaz, Dinh, Christopher, Nasser, Waleed, Kuspa, Adam, Santhanam, Balaji, Chen, Rui, Shaulsky, Gad, Parikh, Anup, Rot, Gregor   +10 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genes and physiological strategies in bacterial antibiotic resistance

Frontiers in Microbiology
Bacteria display an incredible genetic plasticity, which enables them to adapt to various environmental stressors, such as antibiotic compounds that may imperil their existence. Bacterial resistance mechanisms include degradative enzymes, inactivation of
Muhammad Shahid Nadeem, Rabia Rasool, Muhammad Afzal, Inam Ullah, Bibi Nazia Murtaza, Rabeea Mustafa Ali Daoub, Kamel Chaieb, Sami I. Alzarea, Imran Kazmi, Ghulam Md Ashraf   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Metagenome-Wide Association of Microbial Determinants of Host Phenotype in Drosophila melanogaster

mBio, 2014
Animal-associated bacteria (microbiota) affect host behaviors and physiological traits. To identify bacterial genetic determinants of microbiota-responsive host traits, we employed a metagenome-wide association (MGWA) approach in two steps.
John M. Chaston, Peter D. Newell, Angela E. Douglas   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source