Results 131 to 140 of about 3,158,601 (308)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Who Possesses Drug Resistance Genes in the Aquatic Environment? : Sulfamethoxazole (SMX) Resistance Genes among the Bacterial Community in Water Environment of Metro-Manila, Philippines

Frontiers in Microbiology, 2013
Recent evidence has shown that antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) are ubiquitous in natural environments, including sites considered pristine.
Satoru eSuzuki, Mitsuko eOgo, Todd W Miller, Akiko eShimizu, Hideshige eTakada, Maria Auxilia eSiringan   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Impairment of the bacterial biofilm stability by triclosan [PDF]

, 2012
The accumulation of the widely-used antibacterial and antifungal compound triclosan (TCS) in freshwaters raises concerns about the impact of this harmful chemical on the biofilms that are the dominant life style of microorganisms in aquatic systems ...
Hubas, Cedric Roger Rene, Lubarsky, Helen, David M. Paterson (170830), Paterson, David Maxwell, Lubarsky Helen V., Hubas, Cédric, Sebastian Behrens, Helen V. Lubarsky (170802), Paterson, David, Sabine U Gerbersdorf, Cédric Hubas (170814), Paterson David M., Francesco Ricciardi (170821), Francesco Ricciardi, Lubarsky, Helen V., Hubas Cédric, Gerbersdor, Sabine U., Behrens Sebastian, David M Paterson, Cédric Hubas, Ricciardi, Francesco, Paterson, David M., Helen V Lubarsky, Gerbersdorf, Sabine, Gerbersdorf Sabine U., Gerbersdorf, Sabine Ulrike, Ricciardi Francesco, Behrens, Sebastian, Sebastian Behrens (60313), Sabine U. Gerbersdorf (170809)   +29 more
core   +1 more source

Detection of adhesion genes in Enterobacter spp. Isolated from clinical cases in Al-najaf city [PDF]

Ain Shams Medical Journal
Background and Aim of the study: Enterobacter spp. is also an important nosocomial pathogen that causes bacteremia and infections of the lower respiratory tract, urinary tract, and burns, as well as endocarditis, septic arthritis, and skin and soft ...
Taif Al-Saadi, Sara Yassir, Fadhil sead, Mona Ismail, Faiz katab   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Expression regulation of bacterial lipase genes: a review

Frontiers in Microbiology
Microbial lipases constitute the primary source of commercialized and industrial lipases, and they are extensively utilized across numerous industrial sectors.
Dai-ming Zha, Yun-jun Yan
doaj   +1 more source

Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species

Frontiers in Microbiology, 2017
This review gathers recent information about genomic and transcriptomic studies in the Corynebacterium genus, exploring, for example, prediction of pathogenicity islands and stress response in different pathogenic and non-pathogenic species. In addition,
Alberto Oliveira, Leticia C. Oliveira, Flavia Aburjaile, Leandro Benevides, Sandeep Tiwari, Syed B. Jamal, Arthur Silva, Henrique C. P. Figueiredo, Preetam Ghosh, Ricardo W. Portela, Vasco A. De Carvalho Azevedo, Alice R. Wattam   +11 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source