Results 101 to 110 of about 3,158,601 (308)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Bacterial human virulence genes across diverse habitats as assessed by in silico analysis of environmental metagenomes

Frontiers in Microbiology, 2016
The occurrence and distribution of clinically relevant bacterial virulence genes across natural (non-human) environments is not well understood. We aimed to investigate the occurrence of homologues to bacterial human virulence genes in a variety of ...
Ditte Andreasen Søborg, Niels Bohse Hendriksen, Jan H. Christensen, Mogens Kilian, Niels Kroer   +4 more
doaj   +1 more source

Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization inClostridium kluyveri [PDF]

, 2009
It has been suggested that ethanol metabolism in the strict anaerobe Clostridium kluyveri occurs within a metabolosome, a subcellular proteinaceous bacterial microcompartment. Two bacterial microcompartment shell proteins [EtuA (ethanol utilization shell
Seyedarabi, Arefeh, Warren, Martin J, Warren, Martin J., Pickersgill, Richard W, Parsons, Joshua B., Heldt, Dana, Parsons, Joshua B, Ladikis, Dimitrios, Frank, Stefanie, Pickersgill, Richard W., Ladakis, Dimitrios   +10 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Steps toward broad-spectrum therapeutics : discovering virulence-associated genes present in diverse human pathogens [PDF]

, 2009
© 2009 Stubben et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Karlyshev, Andrey V., Gans, Jason D, Oyston, Petra C. F., Ford, Donna C., Gans, Jason D., Wolinsky Murray, Titball, Richard W., Cooper, Ian A, Karlyshev, Andrey, Wren, Brendan W, Cooper Ian A, Duffield Melanie L, Duffield, Melanie, Ford Donna C, Lingard, Bryan, Ford, Donna C, Stubben, Chris J., Wren, Brendan W., Oyston, Petra CF, Karlyshev, Andrey V, Titball, Rick W, Lingard, Brian, Duffield, Melanie L, Karlyshev Andrey V, Gans Jason D, Oyston Petra CF, Song, Jian, Stubben, Chris J, Oyston, Petra C F, Titball Rick W, de Rochefort Anna, Stubben Chris J, Wren Brendan W, Lingard Bryan, Wolinsky, Murray, de Rochefort, Anna, Cooper, Ian A., Song Jian   +37 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Bacterial SET domain proteins and their role in eukaryotic chromatin modification

Frontiers in Genetics, 2014
It has been shown by many researchers that SET-domain containing proteins modify chromatin structure and, as expected, genes coding for SET-domain containing proteins have been found in all eukaryotic genomes sequenced to date.
Raúl eAlvarez-Venegas
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Tools for characterization of Escherichia coli genes of unknown function [PDF]

, 2002
Despite the power of sequencing and of emerging high-throughput technologies to collect data rapidly, the definitive functional characterization of unknown genes still requires biochemical and genetic analysis in case-by-case studies. This often involves
Masters, Millicent, Merlin, Christophe, McAteer, Sean, Masters, Millicent/Mrs Donachie   +3 more
core   +1 more source