Results 81 to 90 of about 801,477 (317)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Targeting bacterial biofilm-related genes with nanoparticle-based strategies

Frontiers in Microbiology
Persistent infection caused by biofilm is an urgent in medicine that should be tackled by new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns of the persistent infection due to biofilm ...
Shima Afrasiabi, Alireza Partoazar
doaj   +1 more source

Prediction of Sinorhizobium meliloti sRNA genes and experimental detection in strain 2011

, 2008
Valverde C, Livny J, Schlüter J-P, Reinkensmeier J, Becker A, Parisi G. Prediction of Sinorhizobium meliloti sRNA genes and experimental detection in strain 2011. BMC Genomics.
Schlüter, Jan-Philip, Reinkensmeier, Jan, Valverde, Claudio, Valverde Claudio, Parisi Gustavo, Livny Jonathan, Livny, Jonathan, Parisi, Gustavo, Becker Anke, Reinkensmeier Jan, Schlüter Jan-Philip, Becker, Anke   +11 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Molecular Marker Detection and Analysis of Resistance to Bacterial Blight in 72 Rice Germplasms

Guangdong nongye kexue
【Objective】In order to address the challenges posed by bacterial blight to the safety of rice production and to clarify the status of bacterial blight resistance genes in 72 rice germplasm materials.【Method】The total DNA of 72 rice germplasm materials ...
Ying HE, Zeliang XU, Hong ZHANG, Hongkai ZHOU, Junjie MO, Shan YANG   +5 more
doaj   +1 more source

Translocation of DNA across bacterial membranes

, 1994
Dreiseikelmann B. Translocation of DNA across bacterial membranes. Microbiological Reviews.
Dreiseikelmann, Brigitte
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Antibiotic Resistance Genes and Bacterial Communities of Farmed Rainbow Trout Fillets (Oncorhynchus mykiss)

Frontiers in Microbiology, 2020
The rise of antibiotic resistance is not only a challenge for human and animal health treatments, but is also posing the risk of spreading among bacterial populations in foodstuffs.
Nicolas Helsens, Nicolas Helsens, Ségolène Calvez, Hervé Prevost, Agnès Bouju-Albert, Aurélien Maillet, Albert Rossero, Dominique Hurtaud-Pessel, Monique Zagorec, Catherine Magras   +9 more
doaj   +1 more source

Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]

, 2014
Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Caly, Delphine L., Joseph Ward (645977), Yvonne McCarthy (109070), Melanie Febrer (185470), Murdoch, Sarah L., Dow, J. Maxwell, Joseph Ward, Robert P. Ryan (108478), Ryan, Robert P., An, Shi Qi, An Shi-qi, Ryan Robert P., Shi-qi An, Robert P Ryan, J. Maxwell Dow (269095), J Maxwell Dow, McCarthy Yvonne, Caly Delphine L., Dow J. Maxwell, An, Shi-qi, Ward Joseph, Delphine L Caly, Yvonne McCarthy, McCarthy, Yvonne, Sarah L Murdoch, Melanie Febrer, Sarah L. Murdoch (645976), Ward, Joseph, Shi-qi An (5661025), Febrer Melanie, Febrer, Melanie, Delphine L. Caly (146386), Murdoch Sarah L.   +32 more
core   +1 more source

Denitrifying genes in bacterial and Archaeal genomes

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002
Denitrification, the reduction of nitrate or nitrite to nitrous oxide or dinitrogen, is the major mechanism by which fixed nitrogen returns to the atmosphere from soil and water. Although the denitrifying ability has been found in microorganisms belonging to numerous groups of bacteria and Archaea, the genes encoding the denitrifying reductases have ...
openaire   +4 more sources