Results 161 to 170 of about 391,292 (303)

The accessibility of the HSV genome during productive infection can vary in different cell types and affect the outcome of infection. [PDF]

mBio
Nosek JM, Dremel SE, DeLuca NA.
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Ohno-miRNAs: miRNA pairs derived from whole-genome duplication. [PDF]

PLoS Comput Biol
Agasso L, Molineris I, Caselle M.
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Development of a DNA damage assay system using stable human hepatocytes. [PDF]

Genes Environ
Mishima M, Izawa K, Tsuda M, Higuchi Y, Uehara S, Suemizu H, Sugiyama KI.   +6 more
europepmc   +1 more source

TBXT Gene Duplication [PDF]

, 2020
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Disruption of androgen receptor-cofactor interactions by the RNA-binding protein FUS/TLS alters androgen signalling in prostate cancer. [PDF]

Oncogene
Brooke GN, Leach DA, Culley RL, Azadova A, Latonen L, Rees E, Alkheilewi MA, Pine AC, Fioretti FM, Reader CS, Powell SM, Reebye V, Waxman J, Visakorpi T, Bevan CL.   +14 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Key role of TLR3 in type I IFN expression and apoptosis induction in IBDV-infected chicken fibroblast cells. [PDF]

Front Cell Infect Microbiol
Diaz-Beneitez E, Concostrina-Martínez L, Cubas-Gaona LL, Martín-Martínez A, Rodríguez JR, Rodríguez JF, Almazán F, Rodríguez D.   +7 more
europepmc   +1 more source