Results 161 to 170 of about 5,097,692 (293)

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant Staphylococcus aureus by Coordination to Rhenium Carbonyl Complexes

open access: yesChemBioChem, Accepted Article.
In this study, a library of rhenium di‐ and tricarbonyl complexes featuring various antimicrobial azoles as monodentate ligands was synthesized and characterized. Their antimicrobial activity was evaluated against both methicillin‐sensitive (MSSA) and methicillin‐resistant (MRSA) Staphylococcus aureus, and selected compounds were also assessed for ...
Kevin Schindler   +12 more
wiley   +1 more source

The Paleozoic Origin of Enzymatic Lignin Decomposition Reconstructed from 31 Fungal Genomes

open access: yesScience, 2012
D. Floudas   +70 more
semanticscholar   +1 more source

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

open access: yesCell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio   +6 more
wiley   +1 more source

Insights into the Mechanism of a Vanadium Bromoperoxidase from the Marine Macro‐Algae Corallina pilulifera for Biocatalytic Halogenation

open access: yesChemCatChem, EarlyView.
A study of crystallographic complexes obtained from vanadium haloperoxidase enzymes can determine key amino acids, leucine, and phenylalanine, that change their structural orientation to allow either chloride or bromide to bind to the enzymes active site, thereby determining halide specificity.
Daniel E. Mitchell   +3 more
wiley   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

open access: yesChemistryEurope, EarlyView.
A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato   +6 more
wiley   +1 more source

Functionalized in Triplicate: A Ring‐by‐Ring Approach to Tailored Prodiginine Derivatives for Site‐Specific Conjugation Through Click Chemistry

open access: yesChemistry – A European Journal, Accepted Article.
The tripyrrole alkaloid prodigiosin and related members of this family are structurally diverse bacterial secondary metabolites. The privileged scaffold accounts for versatile biological activities, e.g., antimicrobial, antitumoral, and immunosuppressive.
T. Moritz Weber, Joerg Pietruszka
wiley   +1 more source

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