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A Novel Biosensor for Ultrasensitive Detection of Fungal Genes
Biosensors and Bioelectronics, 2022Fungal infections are a rapidly increasing public health problem due to their high morbidity and mortality rates, especially in populations with compromised immune systems. Rapid and accurate diagnosis of these diseases is, therefore, necessary to improve the prognosis of afflicted patients.
Muhit Rana +4 more
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Acquisition of prokaryotic genes by fungal genomes
Trends in Genetics, 2010The relevance of horizontal gene transfer (HGT) in eukaryotes is a matter of debate. Recent analyses have shown clear examples in some species such as Candida parapsilosis, but broader surveys are lacking. To assess the impact of HGT in the fungal kingdom, we searched for prokaryotic-derived HGTs in 60 fully sequenced genomes. Using strict phylogenomic
Marina, Marcet-Houben, Toni, Gabaldón
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Chitotriosidase and gene therapy for fungal infections
Cellular and Molecular Life Sciences, 2009Chitotriosidase secreted by activated human macrophages has been implicated in the defence against chitin-bearing pathogens. The antifungal properties of human chitotriosidase were investigated here following retroviral vector-mediated gene transfer of the open reading frame of the chitotriosidase gene into Chinese hamster ovary cells.
Gordon-Thomson, Clare (R8937) +7 more
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Gene targets for fungal and mycotoxin control
Mycotoxin Research, 2006It was initially shown that gallic acid, from hydrolysable tannins in the pelliele of walnut kernels, dramatically inhibits biosynthesis of aflatoxin byAspergillus flavus. The mechanism of this inhibition was found to take place upstream from the gene cluster, including the regulatory gene,aflR, involved in aflatoxin biosynthesis.
J H, Kim +9 more
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Fungal Gene-Encoded Peptidase Inhibitors
Current Medicinal Chemistry, 2013Peptidases can be inhibited by natural or synthetic small-molecule compounds, or by gene-encoded, proteinaceous inhibitors. Small-molecule peptidase inhibitors have been in the spotlight of researchers and pharmaceutical companies for many years. The studies concerning gene-encoded inhibitors are less frequent. The last decade has seen a boom of fungal
V, Bauerová +2 more
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Fungal sex genes—searching for the ancestors
BioEssays, 2008Abstract The sex‐determining genes of fungi reside at one or two specialised regions of the chromosome known as the mating type ( MAT ) loci. The genes are sufficient to determine haploid cell identity, enable compatible mating partners to attract each other, and prepare ...
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