Results 181 to 190 of about 25,117 (218)

Expression of helminth genes in Leishmania: an experimental transfection system to test immunological function

Parasite Immunology, 2008
SUMMARY Functional analysis of genes from parasitic helminths requires, at the present time, heterologous expression. We have adapted the well‐characterized system of transfection in Leishmania protozoal parasites, as a means of analysing the effect of single filarial genes on the mammalian immune system. For example, testing the function of the Brugia
R M, Maizels, N, Gomez-Escobar, L, Prieto-Lafuente, J, Murray, T, Aebischer   +4 more
openaire   +2 more sources

Regulation of HSP70 gene expression during the life cycle of the parasitic helminth Schistosoma mansoni

European Journal of Biochemistry, 1993
Analyses of RNA from different developmental stages of Schistosoma mansoni showed stage‐specific expression of heat‐shock protein 70 (hsp70), which is regulated by a developmental program and by stress. The developmental program, common to hsp70 and other genes (e. g.
S, Neumann, E, Ziv, F, Lantner, I, Schechter   +3 more
openaire   +2 more sources

The helminth Schistosoma mansoni expresses a peptide similar to human beta-endorphin and possesses a proopiomelanocortin-related gene.

The New biologist, 1991
Opioid peptides, a group of transmitter substances with a high degree of phylogenic conservation, have many different functions, including a role in modulation of cells of the immune system. We have postulated the existence of such peptides in the parasite Schistosoma mansoni in view of their possible role in host-parasite interactions.
O, Duvaux-Miret, C, Dissous, J P, Gautron, E, Pattou, C, Kordon, A, Capron   +5 more
openaire   +2 more sources

Activity of the promoter of the hsp70 gene of the parasitic helminth Schistosoma mansoni in the mammalian CHO cell-line

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1995
Functional assay of schistosome promoters is problematic because parasite cell-lines are not available. We found that the hsp70 promoters of S. mansoni and of other eukaryotes reveal similarities in the sequence and organization of the regulatory elements.
R, Levy-Holtzman, I, Schechter
openaire   +2 more sources

Unraveling Helminth-Specific T Cells: Insights from Gene Editing in Strongyloides ratti 2176

The Journal of Immunology
Abstract Description   CD4+ helper 2 (TH2) cells are crucial for protective Type 2 immunity against parasitic helminths, but the importance of antigen-specificity in this context remains a controversial topic.
Fungai Musaigwa, Olufemi Akinkuoutu, Annabel Ferguson, Hannah Dobson, Adriana Stephenson, Ulrich Femoe, Li-Yin Hung, Parvathi Annamalai, Juan Inclan Rico, Heather Rossi, De’Broski R Herbert   +10 more
openaire   +1 more source

Development of primers for the mitochondrial cytochrome c oxidase I gene in digenetic trematodes (Platyhelminthes) illustrates the challenge of barcoding parasitic helminths

Molecular Ecology Resources, 2009
AbstractThe phylum Platyhelminthes is a diverse group of flatworms that includes parasites with serious impacts on human health, animal husbandry, aquaculture and wildlife management. Here we present degenerate primers for the barcode region of the mitochondrial cytochrome c oxidase I (COI) gene in flatworms.
Anna, Moszczynska, Sean A, Locke, J Daniel, McLaughlin, David J, Marcogliese, Teresa J, Crease   +4 more
openaire   +2 more sources

Multiple Lineages of the Mitochondrial Gene NADH Dehydrogenase Subunit 1 (ND1) in Parasitic Helminths: Implications for Molecular Evolutionary Studies of Facultatively Anaerobic Eukaryotes

Journal of Molecular Evolution, 2000
The task of using partial ND1 sequences to infer a phylogeny for species of the genus Paragonimus (Trematoda: Digenea) was complicated by the discovery of at least two ND1 lineages within individual worms. The divergence of the ND1 lineages is shown by phylogenetic analysis not only to predate the divergence of the three Paragonimus species or species ...
Van Herwerden, Lynne, Blair, David, Agatsuma, Takeshi   +2 more
openaire   +3 more sources

Workshop 1M: Helminth antigens and genes

International Journal for Parasitology, 1987
R.M.E. Parkhouse, M.J. Howell
openaire   +1 more source

Cloning of the SmSPO-1 gene preferentially expressed in sporocyst during the life cycle of the parasitic helminth Schistosoma mansoni1.

Biochimica et biophysica acta, 1999
Schistosomes are parasitic helminths with a complex life cycle in human and snail hosts. They express stage-specific genes that conceivably determine distinct properties of the parasite at different developmental stages. Here we report the stage-specific gene SmSPO-1, which is preferentially expressed in sporocysts residing in the snail host.
D, Ram, F, Lantner, E, Ziv, V, Lardans, I, Schechter   +4 more
openaire   +1 more source

Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites

Nature Reviews Immunology, 2023
Dietmar Zaiss, Andrew N J Mckenzie, Christoph S N Klose   +2 more
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