Results 121 to 130 of about 209,288 (267)

Genome-wide identification and functional characterization of <i>LBD</i> transcription factors uncover their stress adaptation mechanisms in tobacco and eggplant. [PDF]

Front Plant Sci
Wu T, Zhang B, Guo Q, Li Y, Li C, He Q, Chen D, Gu G, Chen A, Yang Z, Li W, Xie X.   +11 more
europepmc   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as a candidate gene modulating risk for melanoma and nevi via RAS activation. [PDF]

Am J Hum Genet
Thakur R, Xu M, Thornock AM, Yon J, Anyaso-Samuel S, Lauss M, Rehling T, Bui-Raborn L, Sowards H, Duncan G, Jessop L, Myers T, Chari R, Long E, Funderburk K, Yin J, Hennessey R, Hsieh E, Levin H, Machiela MJ, Zhang T, Jönsson G, Bishop DT, Newton-Bishop J, Nsengimana J, Iles MM, Landi MT, Law MH, Andresson T, Choi J, Zon LI, Shi J, Melanoma Meta-Analysis Consortium, Brown KM.   +33 more
europepmc   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

RAS Family Gene [PDF]

, 2020
openaire   +1 more source

Pan-Ras-In-1 triggers cell wall lysis to eradicate <i>Staphylococcus aureus</i>. [PDF]

iScience
Han W, Guo Y, Shen L, Huang Y, Yuan X, Wang B, Yang C, Hu R, Shang Y, Yu F.   +9 more
europepmc   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Aberrant and ectopic cell populations in restrictive allograft syndrome after lung transplantation. [PDF]

Eur Respir J
Leiber LM, Christian L, Neubert L, Ruwisch J, Yilmaz H, Schwarz EKJ, Langer LT, Kamp JC, Greer M, Haermeyer B, Kühnel M, Werlein C, Justet A, Bergmann AK, Beeckmans H, Ballmaier M, Salman J, Vos R, Knudsen L, Martin U, Vanaudenaerde BM, Yildirim AÖ, Hohlfeld JM, Ius F, Laenger F, Welte T, Falk C, Kaminski N, Jonigk DD, Gottlieb J, Schupp JC.   +30 more
europepmc   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source