Results 91 to 100 of about 74,625 (166)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Major histocompatibility complex II serves as a prognostic biomarker in resectable pulmonary sarcomatoid carcinoma: development of a prediction model. [PDF]

Transl Lung Cancer Res
Wang H, Ye L, Liu X, Li Y, Chen Z, Zhang W, Liu Y, Chen X, Zhao W, Zhang Q, Huang R, Zeng J, Chen S, Li Y, Zhao L, Xu K, He Y.   +16 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Immune Cell-Specific Regulatory Gene Prioritization in Low Back Pain Using Single-Cell eQTL-Informed Mendelian Randomization and Colocalization. [PDF]

J Pain Res
Tao G, Du H, Zeng Z, Yang P.
europepmc   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source

Loss of Major Histocompatibility Complex I and II Function in the Genome of Glacier Lanternfish Provides Insight Into Evolution of Vertebrate Immune Systems. [PDF]

Genome Biol Evol
Solbakken MH, Tørresen OK, Tooming-Klunderud A, Skage M, Bakken T, Jakobsen KS.   +5 more
europepmc   +1 more source

Stage-Dependent Transcriptional Reprogramming of B-Cell Receptor Signaling and Antigen Presentation During Bovine Leukemia Virus-Driven Lymphomagenesis. [PDF]

Anim Genet
Akbarin MM, Farjami Z, Murillo CR, González-Fernández VD, Acevedo-Jiménez GE, de María Ávila-De la Vega L, Álvarez HR.   +6 more
europepmc   +1 more source

Conditional Deletion of Linked, Noncontiguous Genes Using the Cre-Lox System. [PDF]

Cell Mol Gastroenterol Hepatol
Zhu G, Swisa A, Kolev HM, Waite EL, Tigue MA, El-Mekkoussi H, Lee May C, Kaestner KH.   +7 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Recommendations From the Implementation Steering Group for Organ Utilisation Histocompatibility and Immunogenetics Sub-Group: ISOU H&I Sub-Group Recommendations. [PDF]

Int J Immunogenet
Speirs NC, Chalker V, Clark B, Courtney AE, Daga S, Griffin S, Kallon D, Kim JJ, Kosmoliaptsis V, Latham K, Peacock S, Shaw O, Nieto T, Ravanan R, Battle R.   +14 more
europepmc   +1 more source