Results 131 to 140 of about 4,822,162 (317)
The Gene Expression Landscape of Disease Genes
Genome BiologyAbstract Fine-mapping and gene-prioritisation techniques applied to the latest Genome-Wide Association Study (GWAS) results have prioritised hundreds of genes as causally associated with disease. Here we leverage these recently compiled lists of high-confidence causal genes to interrogate where in the body disease ...
Judit García-González +4 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Iatreia, 2010 El Laboratorio Genes Ltda, Laboratorio Nacional de Referencia para los laboratorios que realizan pruebas de paternidad/maternidad con marcadores de ADN, ha diseñado y administrado el Ejercicio Control de Calidad 2009, invitando a participar laboratorios ...
J. J. Builes +18 more
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Genes, dreams and reality: the promises and risks of the new genetics
, 1999 Genes and ...
Casey, Denise K.
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Cardiovascular UltrasoundObjective Exercise-induced premature ventricular complexes (EI-PVCs) are key indicators of subclinical cardiac dysfunction and elevated cardiovascular risk.
Muhammet Geneş, Uygar Çağdaş Yüksel
doaj +1 more source
WHO OWNS YOU? THE CORPORATE GOLD-RUSH TO PATENT YOUR GENES
, 2009 Acknowledgements -- Introduction -- 1. Individual and collective rights in genomic data: preliminary issues -- 2. Ethics and ontology: a brief discourse on method -- 3. The science: genes and phenotypes -- 4. DNA, species, individuals, and persons --
Koepsell, David
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source