Results 121 to 130 of about 4,822,162 (317)
Promoter analysis of epigenetically controlled genes in bladder cancer.
, 2008 DNA methylation is an important epigenetic modification that regulates several genes crucial for tumor development. To identify epigenetically regulated genes in bladder cancer, we performed genome wide expression analyses of eight-bladder cancer cell ...
Panagopoulos, Ioannis +10 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Review: Rethinking environmental enrichment as providing opportunities to acquire information
AnimalEnvironmental enrichment, that is making the environment of animals more complex, was first designed to enhance the welfare and cognitive abilities of captive animals, and was more recently applied to farm animals.
I. Veissier +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]
, 2009 Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Our Genes / Our Choices (2003)
, 2003 The three programs in the three part series are: Who Gets to Know? Genetics and Privacy; Making Better Babies: Genetics and Reproduction; and Genes on Trial: Genetics, Behavior, and the Law. The series is augmented by a Viewer's Guide, transcripts, and
Producer: Films Media Group
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Condición post‑COVID: heterogeneidad terminológica e implicaciones para la investigación
DuazaryLas consecuencias para la salud que persisten más allá de la fase de infección aguda de COVID-19, denominada condición post-COVID-19 (CPC), varían ampliamente y representan una importante carga para la salud pública. Sin embargo, su fisiopatología aún es
Blanca Elena De Oro-Genes
doaj +1 more source