Results 1 to 10 of about 29,074 (248)
Epistasis for head morphology in Drosophila melanogaster
G3: Genes, Genomes, Genetics, 2021 Epistasis—gene–gene interaction—is common for mutations with large phenotypic effects in humans and model organisms. Epistasis impacts quantitative genetic models of speciation, response to natural and artificial selection, genetic mapping, and ...
Ergi D Özsoy +9 more
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Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population [PDF]
Communications BiologyAlcohol use disorder (AUD) is known to have a significant genetic component, yet there remains a gap between its heritability and findings from genome-wide association studies.
Stanislav Listopad, Qian Peng
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Functional bottlenecks can emerge from non-epistatic underlying traits. [PDF]
PLoS Computational BiologyProtein fitness landscapes frequently exhibit epistasis, where the effect of a mutation depends on the genetic context in which it occurs, i.e., the rest of the protein sequence.
Anna Ottavia Schulte +3 more
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Frontiers in Genetics, 2022 The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da +2 more
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Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
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CAPE: an R package for combined analysis of pleiotropy and epistasis. [PDF]
PLoS Computational Biology, 2013 Contemporary genetic studies are revealing the genetic complexity of many traits in humans and model organisms. Two hallmarks of this complexity are epistasis, meaning gene-gene interaction, and pleiotropy, in which one gene affects multiple phenotypes ...
Anna L Tyler +4 more
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Emergence and propagation of epistasis in metabolic networks
eLife, 2021 Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
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A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
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Replication and explorations of high-order epistasis using a large advanced intercross line pedigree. [PDF]
PLoS Genetics, 2011 Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions.
Mats Pettersson +3 more
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A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
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