Results 11 to 20 of about 25,753 (217)
Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance [PDF]
Nature CommunicationsPre-existing mutations can influence subsequent evolution by constraining or opening evolutionary pathways through epistatic interactions. In some cases, global epistasis allows evolutionary pathways to be predicted from the fitness of the genetic ...
Gabriela Petrungaro +4 more
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Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population [PDF]
Communications BiologyAlcohol use disorder (AUD) is known to have a significant genetic component, yet there remains a gap between its heritability and findings from genome-wide association studies.
Stanislav Listopad, Qian Peng
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PLoS Genetics, 2017 Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants ...
Lorin Crawford +3 more
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Functional bottlenecks can emerge from non-epistatic underlying traits. [PDF]
PLoS Computational BiologyProtein fitness landscapes frequently exhibit epistasis, where the effect of a mutation depends on the genetic context in which it occurs, i.e., the rest of the protein sequence.
Anna Ottavia Schulte +3 more
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Frontiers in Genetics, 2022 The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da +2 more
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HIGHER EPISTASIS IN GENETIC ALGORITHMS [PDF]
Bulletin of the Australian Mathematical Society, 2008 AbstractWe study thek-epistasis of a fitness function over a search space. This concept is a natural generalization of that of epistasis, previously considered by Davidor, Suys and Verschoren and Van Hove and Verschoren [Y. Davidor, in:Foundations of genetic algorithms, Vol. 1, (1991), pp. 23–25; D. Suys and A. Verschoren, ‘Proc Int. Conf.
Iglesias, M.T. +3 more
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Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
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CAPE: an R package for combined analysis of pleiotropy and epistasis. [PDF]
PLoS Computational Biology, 2013 Contemporary genetic studies are revealing the genetic complexity of many traits in humans and model organisms. Two hallmarks of this complexity are epistasis, meaning gene-gene interaction, and pleiotropy, in which one gene affects multiple phenotypes ...
Anna L Tyler +4 more
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Emergence and propagation of epistasis in metabolic networks
eLife, 2021 Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
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A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
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