Results 11 to 20 of about 29,074 (248)
PLoS Genetics, 2017 Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants ...
Lorin Crawford +3 more
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The causes of epistasis in genetic networks [PDF]
Evolution; international journal of organic evolution, 2011 Epistasis refers to the non-additive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign.
Elena, Santiago F. +6 more
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On the relationship between epistasis and genetic variance heterogeneity [PDF]
Journal of Experimental Botany, 2017 Epistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from earlier analyses of experimental data to illustrate the ...
Forsberg, Simon K. G., +3 more
core +4 more sources
Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
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Higher epistasis in genetic algorithms [PDF]
Bulletin of the Australian Mathematical Society, 2008 : We study the k-epistasis of a fitness function over a search space. This concept is a natural generalization of that of epistasis, previously considered by Davidor, Suys and Verschoren and Van Hove and Verschoren [Y.Davidor, in: Foundations of genetic ...
Iglesias, M.T. +3 more
core +3 more sources
Estimating directional epistasis
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
doaj +2 more sources
Inferring Epistasis from Genetic Time-series Data
Molecular Biology and Evolution, 2022 Epistasis refers to fitness or functional effects of mutations that depend on the sequence background in which these mutations arise. Epistasis is prevalent in nature, including populations of viruses, bacteria, and cancers, and can contribute to the ...
Sohail, MS +4 more
core +5 more sources
Mechanistic causes of sign epistasis and its applications [PDF]
Frontiers in GeneticsMapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang +5 more
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Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
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Considerations in the search for epistasis [PDF]
Genome BiologyEpistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units.
Marleen Balvert +26 more
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