Results 31 to 40 of about 29,074 (248)

Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution

Nature Communications, 2023
Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda, Charlotte M. Miton, Nobuhiko Tokuriki   +2 more
doaj   +1 more source

Influence of epistasis on response to genomic selection using complete sequence data

Genetics Selection Evolution, 2017
Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris, Zulma G. Vitezica, Andres Legarra, Miguel Pérez-Enciso   +3 more
doaj   +1 more source

Simulating evolution in asexual populations with epistasis [PDF]

, 2021
I show how to use OncoSimulR, software for forward-time genetic simulations, to simulate evolution of asexual populations in the presence of epistatic interactions. This chapter emphasizes the specification of fitness and epistasis, both directly (i.e.,
Díaz-Uriarte, Ramón, Ramon Diaz-Uriarte, Díaz Uriarte, Ramón   +2 more
core   +1 more source

The effect of epistasis on sexually antagonistic genetic variation [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2014
There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between ...
G. Arnqvist, N. Vellnow, L. Rowe
openaire   +3 more sources

Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits.

PLoS Genetics, 2016
To date, most genetic analyses of phenotypes have focused on analyzing single traits or analyzing each phenotype independently. However, joint epistasis analysis of multiple complementary traits will increase statistical power and improve our ...
Futao Zhang, Futao Zhang, Dan Xie, Meimei Liang, Momiao Xiong   +4 more
doaj   +1 more source

Widespread genetic epistasis among cancer genes [PDF]

Nature Communications, 2014
Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Xiaoyue, Wang, Audrey Q, Fu, Megan E, McNerney, Kevin P, White   +3 more
openaire   +2 more sources

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]

, 2012
Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Darina Czamara, Seiderer, J., Ochsenkühn, Thomas, Nazanin Karbalai (177982), Beigel, F., Julia Seiderer (107820), Wagner, Johanna, Glas, J., Cornelia Tillack (174718), Friedrich, Matthias, Christian Steib (174731), Czamara, D., Jürgen Glas (107816), Tillack, Cornelia, Nazanin Karbalai, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Karbalai, N., Göke, B., Florian Beigel (174724), Thomas Ochsenkühn, Beigel, Florian, Matthias Friedrich (174721), Thomas Ochsenkühn (174734), Stallhofer, J., Ochsenkühn, T., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Cornelia Tillack, Julia Diegelmann, Steib, Christian, Göke, Burkhard, Wagner, J., Friedrich, M., Seiderer, Julia, Glas, Jürgen, Diegelmann, J., Burkhard Göke (109829), Martin Wetzke, Burkhard Göke, Christian Steib, Stephan Brand, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Julia Diegelmann (107830), Jürgen Glas, Johanna Wagner (174709), Johanna Wagner, Wetzke, Martin, Karbalai, Nazanin, Diegelmann, Julia, Johannes Stallhofer (174728), Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten, Tillack, C.   +63 more
core   +1 more source

GenEpi: gene-based epistasis discovery using machine learning

BMC Bioinformatics, 2020
Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang, June-Tai Wu, Ming-Yi Hong, Yi-An Tung, Ping-Han Hsieh, Sook Wah Yee, Kathleen M. Giacomini, Yen-Jen Oyang, Chien-Yu Chen, for the Alzheimer’s Disease Neuroimaging Initiative   +9 more
doaj   +1 more source

Estimation of epistasis and genetic components of variance for different traits in cucumber (Cucumis sativus)

The Indian Journal of Agricultural Sciences, 2021
To estimate epistasis and components of genetic variance a study was carried out during 2016 and 2017 at Experimental Research Farm of Department of Vegetable Science, Dr YSP UH & F Nauni, Solan, (HP) and data were recorded for different qualitative and
REENA KUMARI, RAMESH KUMAR, MEENU GUPTA
doaj   +1 more source

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]

Journal of Biomedicine and Biotechnology, 2010
Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Priest, Nicholas K., Wade, Michael J.
openaire   +2 more sources