Results 31 to 40 of about 25,753 (217)

PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES [PDF]

Evolution, 2005
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete.
Weinreich, Daniel M., Watson, Richard A., Chao, Lin   +2 more
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Epistasis regulates genetic control of cardiac hypertrophy

Nature Cardiovascular Research, 2023
Abstract The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy.
Qianru Wang, Tiffany M. Tang, Michelle Youlton, Chad S. Weldy, Ana M. Kenney, Omer Ronen, J. Weston Hughes, Elizabeth T. Chin, Shirley C. Sutton, Abhineet Agarwal, Xiao Li, Merle Behr, Karl Kumbier, Christine S. Moravec, W. H. Wilson Tang, Kenneth B. Margulies, Thomas P. Cappola, Atul J. Butte, Rima Arnaout, James B. Brown, James R. Priest, Victoria N. Parikh, Bin Yu, Euan A. Ashley   +23 more
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Epistasis: obstacle or advantage for mapping complex traits? [PDF]

PLoS ONE, 2010
Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven, George Casella, Lauren M McIntyre   +2 more
doaj   +1 more source

Genetic Dissection of Cytonuclear Epistasis in Line Crosses [PDF]

Genetics, 2007
Abstract Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL × cytoplasm interactions to the phenotypic ...
Zaixiang, Tang, Xuefeng, Wang, Zhiqiu, Hu, Zefeng, Yang, Chenwu, Xu   +4 more
openaire   +2 more sources

Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution

Nature Communications, 2023
Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda, Charlotte M. Miton, Nobuhiko Tokuriki   +2 more
doaj   +1 more source

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]

Journal of Biomedicine and Biotechnology, 2010
Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Priest, Nicholas K., Wade, Michael J.
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Influence of epistasis on response to genomic selection using complete sequence data

Genetics Selection Evolution, 2017
Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris, Zulma G. Vitezica, Andres Legarra, Miguel Pérez-Enciso   +3 more
doaj   +1 more source

Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits.

PLoS Genetics, 2016
To date, most genetic analyses of phenotypes have focused on analyzing single traits or analyzing each phenotype independently. However, joint epistasis analysis of multiple complementary traits will increase statistical power and improve our ...
Futao Zhang, Futao Zhang, Dan Xie, Meimei Liang, Momiao Xiong   +4 more
doaj   +1 more source

Genetic epistasis in female suicide attempters

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012
Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction).Genomic DNA from peripheral blood samples was analyzed using SNPlex ...
Pablo, Fernández-Navarro, Concepción, Vaquero-Lorenzo, Hilario, Blasco-Fontecilla, Montserrat, Díaz-Hernández, Mònica, Gratacòs, Xabier, Estivill, Javier, Costas, Ángel, Carracedo, José, Fernández-Piqueras, Jerónimo, Saiz-Ruiz, Enrique, Baca-Garcia   +10 more
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The effect of epistasis on sexually antagonistic genetic variation [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2014
There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between ...
G. Arnqvist, N. Vellnow, L. Rowe
openaire   +3 more sources