Results 51 to 60 of about 29,074 (248)

Capacitating Epistasis-Detection and Role in the Genetic Architecture of Complex Traits

, 2015
Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the ...
Sveriges lantbruksuniversitet., Carlborg, Örjan,, Pettersson, Mats,   +2 more
core   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

eQTL epistasis – challenges and computational approaches

Frontiers in Genetics, 2013
The determination of eQTL epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step towards the thorough understanding of gene regulation.
Yang eHuang, Stefan eWuchty, Teresa M Przytycka   +2 more
doaj   +1 more source

Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments. [PDF]

PLoS ONE, 2014
Improving yield is a major objective for cotton breeding schemes, and lint yield and its three component traits (boll number, boll weight and lint percentage) are complex traits controlled by multiple genes and various environments.
Yinhua Jia, Xiwei Sun, Junling Sun, Zhaoe Pan, Xiwen Wang, Shoupu He, Songhua Xiao, Weijun Shi, Zhongli Zhou, Baoyin Pang, Liru Wang, Jianguang Liu, Jun Ma, Xiongming Du, Jun Zhu   +14 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Initial mutations direct alternative pathways of protein evolution

, 2011
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser, Tawfik Dan S., Salverda, M.L.M., Merijn L M Salverda, Hoekstra, R.F., Salverda Merijn L. M., Dellus, E., John van der Oost, Alfons J M Debets, Visser, J.A.G.M., de, Gorter Florien A., de Visser J. Arjan G. M., Florien A Gorter, Dellus Eynat, Dan S Tawfik, Gorter, F.A., Debets Alfons J. M., van der Oost John, Eynat Dellus, Hoekstra Rolf F., Debets, A.J.M., Oost, J., van der, J. Arjan G. M. de Visser, Merijn L. M. Salverda, Tawfik, D.S., Florien A. Gorter, Alfons J. M. Debets, Rolf F Hoekstra, de Visser, J.A.G.M., van der Oost, J., Rolf F. Hoekstra, Dan S. Tawfik   +31 more
core   +1 more source

Epistasis dominates the genetic architecture of Drosophila quantitative traits [PDF]

, 2018
Epistasis-nonlinear genetic interactions between polymorphic loci-is the genetic basis of canalization and speciation, and epistatic interactions can be used to infer genetic networks affecting quantitative traits.
Magwire, Michael M, Huang, Wen, Duncan, Laura H, Stone, Eric, Carbone, Mary Anna, Zhu, Dianhui, Lawrence, Faye, Richards, Stephen, Ayroles, Julien F, Jordan, Katherine W, Anholt, Robert R H   +10 more
core   +1 more source

Generation means analysis of physiological and agronomical targeted traits in durum wheat (Triticum durum Desf.) cross

Revista Facultad Nacional de Agronomía Medellín, 2019
Genetic parameters such as leaf relative water content, leaf chlorophyll content, plant height, above-ground biomass, harvest index, grain yield, and grain yield components of Bousselam/Mrb5 durum wheat (Triticum durum Desf.) cross were estimated based ...
Manel Salmi, Amar Benmahammed, Laid Benderradji, Zine El Abidine Fellahi, Hamenna Bouzerzour, Abdelmalek Oulmi, Abdelkader Benbelkacem   +6 more
doaj   +1 more source

Rheumatoid arthritis identification using epistasis analysis through computational models

Biomedical and Biotechnology Research Journal, 2020
Rheumatoid arthritis (RA) is an autoimmune disorder that damages joints irreversibly. Many RA illnesses were also related to complex genetic characteristics and genetic interactions as well.
R Manavalan, S Priya
doaj   +1 more source

Lower-order effects adjustment in quantitative traits model-based multifactor dimensionality reduction. [PDF]

PLoS ONE, 2012
Identifying gene-gene interactions or gene-environment interactions in studies of human complex diseases remains a big challenge in genetic epidemiology.
Jestinah M Mahachie John, Tom Cattaert, François Van Lishout, Elena S Gusareva, Kristel Van Steen   +4 more
doaj   +1 more source