Results 61 to 70 of about 29,074 (248)

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Statistical Modeling of Epistasis and Linkage Decay using Logic Regression

, 2008
Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
Jean-Luc Jannink, Walt F. Mahaffee, John A. Henning, Peter Szucs, Thomas B. Parker   +4 more
core   +1 more source

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 2006
Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

The challenge of detecting epistasis (G×G Interactions): Genetic Analysis Workshop 16

, 2009
Interest is increasing in epistasis as a possible source of the unexplained variance missed by genome-wide association studies. The Genetic Analysis Workshop 16 Group 9 participants evaluated a wide variety of classical and novel analytical methods for ...
Mariza de Andrade, Corinne D. Engelman, Chien‐Hsun Huang, Li Yao, de Andrade, Mariza, An, Ping, Dube, Marie-Pierre, Pritam Chanda, Ping An, Clarke, Geraldine M., Manning, Alisa K., Jung, Jeesun, Engelman, Corinne D., Doerthe Malzahn, Tian Zheng, Zheng, Tian, Yao, Li, Mukherjee, Odity, Huang, Chien-Hsun, Michael A. Province, Jia Li, Geraldine M. Clarke, Yao, L. I., Kovac, Ilija P., Odity Mukherjee, Marie‐Pierre Dubé, Malzahn, Doerthe, Jeesun Jung, Liang, Xueying, Chanda, Pritam, Li, Jia, Alisa K. Manning, Xueying Liang, Province, Michael A., Ilija P. Kovac, Robert Culverhouse, Culverhouse, Robert   +36 more
core   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

Epistasis analysis with global transcriptional phenotypes [PDF]

, 2005
Classical epistasis analysis can determine the order of function of genes in pathways using morphological, biochemical and other phenotypes. It requires knowledge of the pathway's phenotypic output and a variety of experimental expertise and so is ...
Demsar, Janez, Ezgi O Booth, Adam Kuspa, Zupan, Blaz, Paul Hill, Gad Shaulsky, Hill, Paul, Van Driessche, Nancy, Juvan, Peter, Shaulsky, Gad, Peter Juvan, Kuspa, Adam, Nancy Van Driessche, Blaz Zupan, Booth, Ezgi O, Janez Demsar   +15 more
core   +1 more source

EPISTASIS BETWEEN NEW MUTATIONS AND GENETIC BACKGROUND AND A TEST OF GENETIC CANALIZATION [PDF]

Evolution, 2001
The importance for fitness of epistatic interactions among mutations is poorly known, yet epistasis can exert important effects on the dynamics of evolving populations. We showed previously that epistatic interactions are common between pairs of random insertion mutations in the bacterium Escherichia coli. In this paper, we examine interactions between
S F, Elena, R E, Lenski
openaire   +2 more sources

A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis

BMC Genomics, 2008
Background The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease.
Galan Jose, Quintas Antonio, Royo Jose, Sáez María, Bermudo Fernando, González-Pérez Antonio, Gayán Javier, Morón Francisco, Ramirez-Lorca Reposo, Real Luis, Ruiz Agustín   +10 more
doaj   +1 more source

Positive epistasis drives the acquisition of multidrug resistance. [PDF]

PLoS Genetics, 2009
The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact ...
Sandra Trindade, Ana Sousa, Ana Sousa, Karina Bivar Xavier, Francisco Dionisio, Miguel Godinho Ferreira, Isabel Gordo   +6 more
doaj   +1 more source