Results 71 to 80 of about 29,074 (248)
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Epistasis in complex human traits
, 2006 Epistasis (gene-gene interaction) is a universal component of common complex genetic traits. The identification and characterization of epistatic interactions are crucial to a full understanding of the complex genetic mechanisms that underlie human ...
Bell, Jordana Tzenova. +1 more
core +1 more source
International Journal of Cancer, EarlyView.Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens +14 more
wiley +1 more source
Speciation Genetics: Epistasis, Conflict and the Origin of Species [PDF]
Current Biology, 2007 Evolutionary biologists have long recognized that the sterility and inviability of species hybrids must involve incompatible epistatic interactions between two (or more) genes. The first pair of such hybrid incompatibility genes has now been identified.
openaire +2 more sources
Contribution of genetic effects to genetic variance components with epistasis and linkage disequilibrium [PDF]
BMC Genetics, 2009 Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confusion about the relationship between these two
Zeng Zhao-Bang, Wang Tao
openaire +3 more sources
Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
doaj +1 more source
Beyond natural variation: The era of rational design in plant immunity
New Plant Protection, EarlyView.Abstract The evolutionary arms race between crops and pathogens has reached a critical impasse: pathogen adaptation consistently outpaces the development of resistant varieties through conventional breeding. This growing imbalance highlights the need to move beyond the exclusive reliance on natural variation toward more predictive and design‐oriented ...
Hengjing Li +3 more
wiley +1 more source
Genetic mapping of sterile genes with epistasis in backcross designs [PDF]
Heredity, 2013 The mapping of sterile genes is an essential issue, which should be solved for the investigation of sterility mechanism in wide hybridization of plants. However, the methods formerly developed cannot address the problem of mapping sterile loci with epistasis.
S, Xie, J, Chen, B, Walsh
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Frontiers in Plant Science, 2018 An “immortalized F2” (IF2) population and two reciprocal backcross (HSBCF1 and MARBCF1) populations were constructed to investigate the genetic bases of fiber quality traits in upland cotton across four different environments.
Cong Li +12 more
doaj +1 more source
BioData Mining, 2021 Background In genome-wide association studies the extent and impact of confounding due to population structure have been well recognized. Inadequate handling of such confounding is likely to lead to spurious associations, hampering replication, and the ...
Fentaw Abegaz +9 more
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