Results 71 to 80 of about 25,753 (217)

A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis

BMC Genomics, 2008
Background The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease.
Galan Jose, Quintas Antonio, Royo Jose, Sáez María, Bermudo Fernando, González-Pérez Antonio, Gayán Javier, Morón Francisco, Ramirez-Lorca Reposo, Real Luis, Ruiz Agustín   +10 more
doaj   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Genetic epistasis regulates amyloid deposition in resilient aging [PDF]

Alzheimer's & Dementia, 2017
AbstractIntroductionThe brain‐derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer's disease (AD) risk factors. Specifically, variants within the SORL1 gene determine BDNF's ability to reduce amyloid β (Aβ) in vitro. We sought to test whether functional BDNF variation interacts with SORL1 genotypes to influence expression and ...
Felsky, Daniel, Xu, Jishu, Chibnik, Lori, Schneider, Julie, Knight, Jo, Kennedy, James L., Bennett, David A., De Jager, Philip L., Voineskos, Aristotle N.   +8 more
openaire   +3 more sources

Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease

Scientific Reports, 2022
Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang, Timothy Shin Heng Mak, Saloni Dattani, Maria-Merce Garcia-Barcelo, Alexander Xi Fu, Kevin Y. Yip, Elly Sau-Wai Ngan, Paul Kwang-Hang Tam, Clara Sze-Man Tang, Pak Chung Sham   +9 more
doaj   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

The causes of epistasis in genetic networks.

Evolution; international journal of organic evolution, 2012
Epistasis refers to the non-additive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases ...
Macía, Javier, Solé, Ricard V., Elena, Santiago F.   +2 more
openaire   +3 more sources

Lettuce Genetics: Inheritance, Linkage, and Epistasis [PDF]

Journal of the American Society for Horticultural Science, 1992
Two new lettuce (Luctuca sativa L.) genes are described and named truncated leaf (tn), and sickly (si). A gene for reflexed involucre is identical to that previously described in wild lettuce (L.
openaire   +1 more source

QTL Mapping and Heterosis Analysis for Fiber Quality Traits Across Multiple Genetic Populations and Environments in Upland Cotton

Frontiers in Plant Science, 2018
An “immortalized F2” (IF2) population and two reciprocal backcross (HSBCF1 and MARBCF1) populations were constructed to investigate the genetic bases of fiber quality traits in upland cotton across four different environments.
Cong Li, Hurong Yu, Cheng Li, Tianlun Zhao, Yating Dong, Xiaolei Deng, Jiahui Hu, Yi Zhang, Fan Zhang, M. K. Daud, M. K. Daud, Jinhong Chen, Shuijin Zhu   +12 more
doaj   +1 more source

Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure

BioData Mining, 2021
Background In genome-wide association studies the extent and impact of confounding due to population structure have been well recognized. Inadequate handling of such confounding is likely to lead to spurious associations, hampering replication, and the ...
Fentaw Abegaz, François Van Lishout, Jestinah M. Mahachie John, Kridsadakorn Chiachoompu, Archana Bhardwaj, Diane Duroux, Elena S. Gusareva, Zhi Wei, Hakon Hakonarson, Kristel Van Steen   +9 more
doaj   +1 more source