Results 91 to 100 of about 25,247 (211)

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

BioData Mining, 2019
Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret, Jestinah M. Mahachie John, Elena S. Gusareva, Kristel Van Steen   +3 more
doaj   +1 more source

Functional Genetic Variation in Ubiquitin D Promoter Influences Susceptibility to Atopic Dermatitis

Clinical &Experimental Allergy, EarlyView.
Yi Ying Eliza Lim, Yang Yie Sio, Terence Yin Weng Lam, Yee‐How Say, Kavita Reginald, Fook Tim Chew   +5 more
wiley   +1 more source

A Century of Understanding and Harnessing Heterosis

Plant Breeding, EarlyView.
ABSTRACT Heterosis has shaped modern plant breeding since Darwin's 19th century observations that outcrossing restores vigour lost through selfing. While 100 years old, its mechanistic basis and deployability remain actively debated. Classical models of dominance, overdominance and epistasis provided the foundation for hybrid breeding and converted ...
Mohsen Mohammadi
wiley   +1 more source

Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis

BioData Mining
Background Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits.
Zhendong Sha, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Jason H. Moore, Ting Hu   +6 more
doaj   +1 more source

Artificial intelligence‐powered plant phenomics: Progress, challenges, and opportunities

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Artificial intelligence (AI), a key driver of the Fourth Industrial Revolution, is being rapidly integrated into plant phenomics to automate sensing, accelerate data analysis, and support decision‐making in phenomic prediction and genomic selection.
Xu Wang, Daeun Choi, Damian Adams, Jaehyun Ahn, Kelly Balmant, Raquel Dias, Carlos D. Messina, Rafael Muñoz‐Carpena, Vance M. Whitaker, Haipeng Yu, Ziwen Yu, Chang Zhao, Changying Li   +12 more
wiley   +1 more source

Privacy-preserving decision tree for epistasis detection

Cybersecurity, 2019
The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj   +1 more source

Combining phenomic and genomic selection for pea breeding improvement

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Pea (Pisum sativum L.) is a strategic crop in the development of sustainable agriculture. However, the genetic gain remains limited despite advances in breeding. Genomic selection holds promise to accelerate varietal improvement, but its high implementation cost restricts its use in crops.
Anthony Klein, Virgilio Freitas, Abdou Wade, Grégoire Aubert, Myriam Naudet‐Huart, Michael Touratier, Jennifer Régulier, Jean‐François Herbommez, Catherine Kraut, Guillaume Roullet, Aude Carlier‐Lézie, Nadim Tayeh, Renaud Rincent, Philippe Dufour, Judith Burstin, Gaëtan Touzy   +15 more
wiley   +1 more source

Orthogonal Decomposition of the Genetic Variance for Epistatic Traits Under Linkage Disequilibrium—Applications to the Analysis of Bateson-Dobzhansky-Müller Incompatibilities and Sign Epistasis

Frontiers in Genetics, 2019
The one-century-old theory of orthogonal genetic variance decomposition originated the field of quantitative genetics and has kept on being improved ever since.
José M. Álvarez-Castro, Rosa M. Crujeiras   +1 more
doaj   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, Volume 159, Issue 7, Page 1715-1734, 1 October 2026.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Weakest link epistasis and the geometry of genetic load

Abstract Because natural selection must optimise multiple traits at once, previous work has suggested that phenotypic dimensionality can substantially worsen the equilibrium fitness defect of a population relative to the phenotypic optimum.
Florian J.F. Labourel, Florence Bansept, David M. McCandlish   +2 more
openaire   +2 more sources