Results 101 to 110 of about 25,753 (217)

FvGI–FvCO–FvFT1 pathway activates FvTFL1 in long days to repress flowering in woodland strawberry (Fragaria vesca)

New Phytologist, EarlyView.
Natural variation of flowering time correlates with FvFT1 and FvTFL1 expression in European Fragaria vesca accessions. Summary Photoperiod is a stable seasonal signal. Although photoperiodic flowering is well understood in short‐day (SD) and long‐day (LD) annual plants, the regulatory mechanisms in perennials remain elusive.
Quan Zhou, Sergei Lembinen, Tuomas Toivainen, Takeshi Kurokura, Guangxun Fan, Paula Elomaa, Elli Koskela, Timo Hytönen   +7 more
wiley   +1 more source

Poor statistical power in population-based association study of gene interaction

BMC Medical Genomics
Background Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype.
Jiarui Ma, Jian Li, Yuqi Chen, Zhen Yang, Yungang He   +4 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Epistasis: Searching for Interacting Genetic Variants Using Crosses [PDF]

G3 Genes|Genomes|Genetics, 2017
Within quantitative genetics, the term “epistasis” is used to broadly describe situations in which combinations of genetic variants show nonadditive phenotypic effects ([Phillips 1998][1], [2008][2]; [Mackay 2014][3]).
openaire   +4 more sources

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

BioData Mining, 2019
Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret, Jestinah M. Mahachie John, Elena S. Gusareva, Kristel Van Steen   +3 more
doaj   +1 more source

Structural Variations Contribute to Subspeciation and Yield Heterosis in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Yield heterosis has been extensively exploited in hybrid breeding, with intersubspecific hybrids often exhibiting the most pronounced effects. However, developing elite hybrids remains a laborious and time‐consuming process. The genetic basis of heterosis has been debated for over a century, hindered largely by the lack of high‐quality genomes.
Zhiwu Dan, Yunping Chen, Wenchao Huang
wiley   +1 more source

Epistasis and immunity: the role of genetic interactions in autoimmune diseases

Immunology, 2012
SummaryAutoimmune disorders are a complex and varied group of diseases that are caused by breakdown of self‐tolerance. The aetiology of autoimmunity is multi‐factorial, with both environmental triggers and genetically determined risk factors. In recent years, it has been increasingly recognized that genetic risk factors do not act in isolation, but ...
Anna M, Rose, Lucy C K, Bell
openaire   +3 more sources

Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis

BioData Mining
Background Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits.
Zhendong Sha, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Jason H. Moore, Ting Hu   +6 more
doaj   +1 more source

Privacy-preserving decision tree for epistasis detection

Cybersecurity, 2019
The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj   +1 more source

Functional Genetic Variation in Ubiquitin D Promoter Influences Susceptibility to Atopic Dermatitis

Clinical &Experimental Allergy, EarlyView.
Yi Ying Eliza Lim, Yang Yie Sio, Terence Yin Weng Lam, Yee‐How Say, Kavita Reginald, Fook Tim Chew   +5 more
wiley   +1 more source