Results 111 to 120 of about 25,247 (211)

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Applications and limitations of AI tools in enzyme design

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Enzymes catalyze various different chemical reactions often with high efficiency and selectivity compared to synthetic catalysts. Advances in protein engineering over the past decades have allowed researchers to design enzymes, improving their catalytic performance and adapting them for specific or entirely novel chemical reactions.
Rosa Teijeiro‐Juiz, Nina Egeler, Grzegorz Jamróg, Marion Ringel, Thomas Brück, Bruno Di Geronimo, Bernhard Loll   +6 more
wiley   +1 more source

Engineering selective amyloid precursor protein inhibitors by machine learning and deep mutational scanning

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Deep mutational scanning (DMS) has proven effective for mapping protein–protein interactions (PPIs), but it cannot provide complete coverage of the mutation landscape, particularly for multi‐mutant variants. To address this limitation, we trained machine‐learning (ML) models on previously generated DMS data for a stabilized amyloid precursor ...
Reut Meiri, Oz Reuveni, Michal Levi, Evette S. Radisky, Niv Papo, Yaron Orenstein   +5 more
wiley   +1 more source

THE EFFECT OF EPISTASIS AND GAMETIC UNBALANCE ON GENETIC LOAD [PDF]

Genetics, 1966
P E, Hansche, S K, Jain, R W, Allard
openaire   +2 more sources

AP‐1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids

Biology of the Cell, Volume 118, Issue 8, August 2026.
We show that in mouse intestinal organoids, AP‐1B is implicated in apical polarity, differentiation in the secretory lineage and proliferation. In particular, we propose that proliferation is controlled by AP‐1B via the mTOR and YAP pathways. Arrows show the functional links that were elucidated in this study, and dotted lines show putative downstream ...
Maela Duclos, Anne Bourdais, Ophélie Nicolle, Alexandre Helpiquet, Grégoire Michaux, Aurélien Bidaud‐Meynard   +5 more
wiley   +1 more source

Distributed transformer for high order epistasis detection in large-scale datasets

Scientific Reports
Understanding the genetic basis of complex diseases is one of the most important challenges in current precision medicine. To this end, Genome-Wide Association Studies aim to correlate Single Nucleotide Polymorphisms (SNPs) to the presence or absence of ...
Miguel Graça, Ricardo Nobre, Leonel Sousa, Aleksandar Ilic   +3 more
doaj   +1 more source

Fungicide Drives De Novo Evolution of Multidrug Resistance in the Plant Growth Promoting Rhizobacterium, Pseudomonas fluorescens

Evolutionary Applications, Volume 19, Issue 8, August 2026.
ABSTRACT Soil microbial communities underpin key ecosystem processes, including plant health, nutrient cycling and primary productivity. In agricultural soils, beneficial soil bacteria are often exposed to multiple stressors simultaneously, including fungicides, antibiotics, and warming temperatures. Despite their ecological importance, little is known
Matthew Kelbrick, James P. J. Hall, Siobhán O'Brien   +2 more
wiley   +1 more source

Genetic and Ecological Management of Pacific Salmon Fisheries for the 21st Century

Fisheries Management and Ecology, Volume 33, Issue 4, Page 633-645, August 2026.
ABSTRACT Based on ecological adaptation theory, tremendous effort is being spent on measures that are eliminating salmon hatcheries and fishing opportunities with the intention of protecting wild runs deemed to be of particular genetic importance to the survival of the species.
Randall E. Brummett, Ian G. Cowx, Devin M. Bartley   +2 more
wiley   +1 more source

Mapping and Functional Characterization of Homologous Genes AhSUCA06 and AhSUCA16 Underlying Sucrose, Oil and Protein Contents in Peanut (Arachis hypogaea L.)

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4844-4859, August 2026.
ABSTRACT Cultivated peanut (Arachis hypogaea L.) is an important oilseed and cash crop, and seed sucrose content (SSC), seed oil content (SOC) and seed protein content (SPC) are key determinants of seed flavour, texture, and overall quality. Identifying quantitative trait loci (QTLs) and candidate genes associated with SSC, SOC and SPC is therefore of ...
Yuzhen Zheng, Feiyan Qi, Lei Shi, Ziqi Sun, Hongfei Liu, Hua Liu, Li Qin, Juan Wang, Chenyang Zhi, Mengmeng Wang, Ziqiang Mo, Stefano Pavan, Xiao Wang, Yaojun Hu, Huanhuan Zhao, Xiaona Li, Wenzhao Dong, Meng Zhang, XiaoDong Dai, Zheng Zheng, Xinyou Zhang   +20 more
wiley   +1 more source

Highly Polygenic Control of Photosynthetic Responses to Nighttime Temperature Studied by Genomic Prediction

Plant, Cell &Environment, Volume 49, Issue 8, Page 5886-5903, August 2026.
ABSTRACT Rising nighttime temperature (Tnight) can reduce crop yields while low Tnight may restrict plant growth and development. Despite quantifiable effects of Tnight, genetic basis underlying plant responses to Tnight remains unclear. We investigated natural variation in long‐term response of effective photosynthetic efficiency (Fq’/Fm’) to Tnight ...
Ana Carolina dos Santos Sá, Alina Bazarova, Andreas Fischbach, Stefan Kesselheim, Benjamin Stich, Shizue Matsubara   +5 more
wiley   +1 more source