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Widespread genetic epistasis among cancer genes [PDF]
Nature Communications, 2014 Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Xiaoyue, Wang +3 more
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GenEpi: gene-based epistasis discovery using machine learning
BMC Bioinformatics, 2020 Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang +9 more
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The Indian Journal of Agricultural Sciences, 2021 To estimate epistasis and components of genetic variance a study was carried out during 2016 and 2017 at Experimental Research Farm of Department of Vegetable Science, Dr YSP UH & F Nauni, Solan, (HP) and data were recorded for different qualitative and
REENA KUMARI, RAMESH KUMAR, MEENU GUPTA
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Epi-GTBN: an approach of epistasis mining based on genetic Tabu algorithm and Bayesian network
BMC Bioinformatics, 2019 Background Mining epistatic loci which affects specific phenotypic traits is an important research issue in the field of biology. Bayesian network (BN) is a graphical model which can express the relationship between genetic loci and phenotype. Until now,
Yang Guo +7 more
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A strategy to apply quantitative epistasis analysis on developmental traits
BMC Genetics, 2017 Background Genetic interactions are keys to understand complex traits and evolution. Epistasis analysis is an effective method to map genetic interactions. Large-scale quantitative epistasis analysis has been well established for single cells.
Marta K. Labocha +3 more
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BMC Genomics, 2022 Background The influence of linkage disequilibrium (LD), epistasis, and inbreeding on genotypic variance continues to be an important area of investigation in genetics and evolution.
José Marcelo Soriano Viana +1 more
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Mechanistic causes of sign epistasis and its applications
Frontiers in GeneticsMapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang +5 more
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Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
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Epistasis and the genetics of human diseases
Comptes Rendus. Biologies, 2005 Epistasis or modifier genes, that is, gene-gene interactions of non-allelic partners, play a major role in susceptibility to common human diseases. This old genetic concept has experienced a major renaissance recently. Interestingly, epistatic genes can make the disease less severe, or make it more severe.
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BMC Plant Biology, 2011 Background Genetic mapping has proven to be powerful for studying the genetic architecture of complex traits by characterizing a network of the underlying interacting quantitative trait loci (QTLs).
Tong Chunfa +7 more
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