Results 21 to 30 of about 25,247 (211)
Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
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Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
Nature Communications, 2023 Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda +2 more
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The effect of epistasis on sexually antagonistic genetic variation [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2014 There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between ...
G. Arnqvist, N. Vellnow, L. Rowe
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Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
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Widespread genetic epistasis among cancer genes [PDF]
Nature Communications, 2014 Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Xiaoyue, Wang +3 more
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Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits.
PLoS Genetics, 2016 To date, most genetic analyses of phenotypes have focused on analyzing single traits or analyzing each phenotype independently. However, joint epistasis analysis of multiple complementary traits will increase statistical power and improve our ...
Futao Zhang +4 more
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Genetic epistasis in female suicide attempters
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012 Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction).Genomic DNA from peripheral blood samples was analyzed using SNPlex ...
Pablo, Fernández-Navarro +10 more
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Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]
Journal of Biomedicine and Biotechnology, 2010 Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Priest, Nicholas K., Wade, Michael J.
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GenEpi: gene-based epistasis discovery using machine learning
BMC Bioinformatics, 2020 Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang +9 more
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The Indian Journal of Agricultural Sciences, 2021 To estimate epistasis and components of genetic variance a study was carried out during 2016 and 2017 at Experimental Research Farm of Department of Vegetable Science, Dr YSP UH & F Nauni, Solan, (HP) and data were recorded for different qualitative and
REENA KUMARI, RAMESH KUMAR, MEENU GUPTA
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