Results 21 to 30 of about 25,753 (217)
Epistasis for head morphology in Drosophila melanogaster
G3: Genes, Genomes, Genetics, 2021 Epistasis—gene–gene interaction—is common for mutations with large phenotypic effects in humans and model organisms. Epistasis impacts quantitative genetic models of speciation, response to natural and artificial selection, genetic mapping, and ...
Ergi D Özsoy +9 more
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Epistasis and Its Implications for Personal Genetics [PDF]
The American Journal of Human Genetics, 2009 The widespread availability of high-throughput genotyping technology has opened the door to the era of personal genetics, which brings to consumers the promise of using genetic variations to predict individual susceptibility to common diseases. Despite easy access to commercial personal genetics services, our knowledge of the genetic architecture of ...
Moore, Jason H., Williams, Scott M.
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Replication and explorations of high-order epistasis using a large advanced intercross line pedigree. [PDF]
PLoS Genetics, 2011 Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions.
Mats Pettersson +3 more
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Dominance, Epistasis and the Genetics of Postzygotic Isolation [PDF]
Genetics, 2000 AbstractThe sterility and inviability of species hybrids can be explained by between-locus “Dobzhansky-Muller” incompatibilities: alleles that are fit on their “normal” genetic backgrounds sometimes lower fitness when brought together in hybrids.
M, Turelli, H A, Orr
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A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
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Haplotypes and Machine Learning Improve Genomic Prediction in Brassica napus. [PDF]
Plant Biotechnol JABSTRACT Genomic selection (GS) is a crop and livestock improvement method suited for predicting complex agronomical traits, while genomic prediction (GP) is the development of GS models prior to their practical use in breeding programs. One of the challenges in GP is accounting for how complex genomic interactions, such as epistasis, affect the ...
MacNish TR +4 more
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Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
Alzheimer’s Research & Therapy, 2021 Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang +4 more
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Estimating directional epistasis
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
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Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross. [PDF]
PLoS Genetics, 2016 The extent and strength of epistasis is commonly unresolved in genetic studies, and observed epistasis is often difficult to interpret in terms of biological consequences or overall genetic architecture. We investigated the prevalence and consequences of
Anna L Tyler +3 more
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On the relationship between epistasis and genetic variance heterogeneity [PDF]
Journal of Experimental Botany, 2017 Abstract Epistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two. This includes an introduction to the relationship between
Forsberg, Simon, Carlborg, Örjan
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