Results 21 to 30 of about 29,074 (248)

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor-chymotrypsin complex. [PDF]

Protein Sci
Abstract Protein–protein interactions (PPIs) are shaped by evolutionary pressures that fine‐tune binding affinities and drive the epistatic relationships that support functional outcomes. Here, we used the complex of bovine pancreatic trypsin inhibitor (BPTI) and chymotrypsin as a model system to study how mutations at one or two positions affect ...
Tzuri N, Kass I, Orenstein Y, Papo N.
europepmc   +2 more sources

Epistasis and Its Implications for Personal Genetics [PDF]

The American Journal of Human Genetics, 2009
The widespread availability of high-throughput genotyping technology has opened the door to the era of personal genetics, which brings to consumers the promise of using genetic variations to predict individual susceptibility to common diseases. Despite easy access to commercial personal genetics services, our knowledge of the genetic architecture of ...
Moore, Jason H., Williams, Scott M.
openaire   +2 more sources

Dominance, Epistasis and the Genetics of Postzygotic Isolation [PDF]

Genetics, 2000
AbstractThe sterility and inviability of species hybrids can be explained by between-locus “Dobzhansky-Muller” incompatibilities: alleles that are fit on their “normal” genetic backgrounds sometimes lower fitness when brought together in hybrids.
M, Turelli, H A, Orr
openaire   +2 more sources

Genetic architecture of angular leaf spot resistance in cultivated strawberry shaped by epistasis and genotype-by-environment interactions. [PDF]

Plant Genome
Abstract Angular leaf spot (ALS), caused by Xanthomonas fragariae, is a bacterial disease that limits strawberry (Fragaria × ananassa) productivity worldwide. Although major resistance loci have been identified in wild Fragaria species, their introgression into elite germplasm remains constrained by linkage drag and inconsistent inheritance. To dissect
Torgeman S, Pincot DDA, Bjornson M, Famula RA, Skillin P, Krill-Brown A, Feldmann MJ.   +6 more
europepmc   +2 more sources

Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Alzheimer’s Research & Therapy, 2021
Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang, David A. Bennett, Philip L. De Jager, Qing-Ye Zhang, Hong-Yu Zhang   +4 more
doaj   +1 more source

Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross. [PDF]

PLoS Genetics, 2016
The extent and strength of epistasis is commonly unresolved in genetic studies, and observed epistasis is often difficult to interpret in terms of biological consequences or overall genetic architecture. We investigated the prevalence and consequences of
Anna L Tyler, Leah Rae Donahue, Gary A Churchill, Gregory W Carter   +3 more
doaj   +1 more source

Epistasis regulates genetic control of cardiac hypertrophy

Nature Cardiovascular Research, 2023
Abstract The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy.
Qianru Wang, Tiffany M. Tang, Michelle Youlton, Chad S. Weldy, Ana M. Kenney, Omer Ronen, J. Weston Hughes, Elizabeth T. Chin, Shirley C. Sutton, Abhineet Agarwal, Xiao Li, Merle Behr, Karl Kumbier, Christine S. Moravec, W. H. Wilson Tang, Kenneth B. Margulies, Thomas P. Cappola, Atul J. Butte, Rima Arnaout, James B. Brown, James R. Priest, Victoria N. Parikh, Bin Yu, Euan A. Ashley   +23 more
openaire   +3 more sources

Genetic epistasis in female suicide attempters

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012
Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction).Genomic DNA from peripheral blood samples was analyzed using SNPlex ...
Pablo, Fernández-Navarro, Concepción, Vaquero-Lorenzo, Hilario, Blasco-Fontecilla, Montserrat, Díaz-Hernández, Mònica, Gratacòs, Xabier, Estivill, Javier, Costas, Ángel, Carracedo, José, Fernández-Piqueras, Jerónimo, Saiz-Ruiz, Enrique, Baca-Garcia   +10 more
openaire   +5 more sources

The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? [PDF]

, 2013
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial.
Ebert, Dieter, Dieter Ebert, Hall, Matthew, Matthew D Hall, Hall, Matthew D.   +4 more
core   +1 more source

PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES [PDF]

Evolution, 2005
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete.
Weinreich, Daniel M., Watson, Richard A., Chao, Lin   +2 more
openaire   +3 more sources