Results 161 to 170 of about 7,597,050 (334)

Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization

, 2010
Jennifer E. Stevens‐Lapsley, Fan Ye, Min Liu, Stephen E. Borst, Christine F. Conover, Kevin E. Yarasheski, Glenn A. Walter, H. Lee Sweeney, Krista Vandenborne   +8 more
openalex   +2 more sources

The breakpoint of a large deletion causing hereditary persistence of fetal hemoglobin occurs within an erythroid DNA domain remote from the beta-globin gene cluster [PDF]

, 1989
EA Feingold, BG Forget
openalex   +1 more source

Cobalamin riboswitches are broadly sensitive to corrinoid cofactors to enable an efficient gene regulatory strategy [PDF]

, 2022
Kristopher J. Kennedy, Florian J. Widner, Olga M. Sokolovskaya, Lina Victoria Innocent, Rebecca R. Procknow, Kenny C. Mok, Michiko E. Taga   +6 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Expression of MHC II genes

, 2005
Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G., Jabrane-Ferrat, N., Kohoutek, J., Peterlin, B. M.   +3 more
core   +2 more sources

Human Tenascin Gene [PDF]

, 1995
Roberto Gherzi, Barbara Carnemolla, Annalisa Siri, Marco Ponassi, Enrica Balza, Luciano Zardi   +5 more
openalex   +1 more source

Comprehensive analysis of prognostic immune-related genes in the tumor microenvironment of hepatocellular carcinoma (HCC)

, 2021
Mengting Li, Hong-Liang Li, Canxin Zhou, Xianpeng Li, Jiande Gong, Changxi Chen, Yi Zhang   +6 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish

Nature Communications
Advancements in CRISPR technology, particularly the development of base editors, revolutionize genetic variant research. When combined with model organisms like zebrafish, base editors significantly accelerate and refine in vivo analysis of genetic ...
Wei Qin, Fang Liang, Sheng-Jia Lin, Cassidy Petree, Kevin Huang, Yu Zhang, Lin Li, Pratishtha Varshney, Philippe Mourrain, Yanmei Liu, Gaurav K. Varshney   +10 more
doaj   +1 more source

Identification of glutamine metabolism-related gene signature to predict colorectal cancer prognosis [PDF]

Yang Xie, Jun Li, Qing Tao, Yonghui Wu, Zide Liu, Chunyan Zeng, Youxiang Chen   +6 more
openalex   +1 more source