Results 171 to 180 of about 4,822,162 (317)

Single-Cell Profiling Identifies Glial Transcriptional Remodeling in the Trigeminal Ganglion After Corneal Injury. [PDF]

Glia
Woodward AM, Martinez-Carrasco R, Argüeso P.   +2 more
europepmc   +1 more source

THE DYNAMIC GENOME AND MENTAL HEALTH: THE ROLE OF GENES AND ENVIRONMENTS IN YOUTH DEVELOPMENT

, 2011
Contributors -- Pt. I. Overviews of research on gene-environment interplay -- 1. A conceptual overview of gene-environment interaction and correlation in a developmental context / Kenneth S. Kendler -- 2. Gene-environment interactions / Rudolf Uher --

core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Identifying Co-Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans. [PDF]

Anim Genet
Nascimento LE, da Silva BPM, de Oliveira CS, Durval MC, Freitas FAO, Ciconello FN, Gervásio IC, Fanalli SL, de Souza Fonseca PA, Gutiérrez-Gil B, de Almeida VV, Cesar ASM.   +11 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MicroRNA-mRNA Networks in Skeletal Muscle of Tailored Pig Models for Dystrophinopathies. [PDF]

J Cachexia Sarcopenia Muscle
Reschke S, Graf A, Hadlich F, Jaudas F, Fröhlich T, Stirm M, Klymiuk N, Krebs S, Wolf E, Ali A.   +9 more
europepmc   +1 more source

ASSISTING REPRODUCTION, TESTING GENES: GLOBAL ENCOUNTERS WITH NEW BIOTECHNOLOGIES

, 2009
Introduction: assisting reproduction, testing genes: global encounters with new biotechnologies / Daphna Birenbaum-Carmeli and Marcia C. Inhorn -- Pt. I. Families and beyond: reproductive technologies and new social orders -- 1. East in West?

core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Genomic Characterization of Aeromonas dhakensis Isolated From a Fatal Dolphin Case. [PDF]

Environ Microbiol Rep
Yamazaki K, Takahashi Y, Yoneda Y, Kashimoto T, Kakuda T.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source