Results 61 to 70 of about 11,860,410 (381)

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

open access: yesFrontiers in Pharmacology
AimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng   +7 more
doaj   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

open access: yesFEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Cavity enhanced transport of excitons

open access: yes, 2015
We show that exciton-type transport in certain materials can be dramatically modified by their inclusion in an optical cavity: the modification of the electromagnetic vacuum mode structure introduced by the cavity leads to transport via delocalized ...
Genes, Claudiu   +3 more
core   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

Estudio genético de la población afrodescendiente del departamento del Chocó con marcadores ligados al cromosoma X

open access: yesIatreia, 2010
Los marcadores genéticos tipo microsatélites del Cromosoma X (X-STR) han recibido creciente atención tan sólo en los últimos 10 años. Se ha demostrado su gran capacidad para aclarar casos complejos de parentesco, tales como abuela paterna - nieta ...
Juan José Builes   +6 more
doaj  

Hybrid cavity mechanics with doped systems

open access: yes, 2014
We investigate the dynamics of a mechanical resonator in which is embedded an ensemble of two-level systems interacting with an optical cavity field. We show that this hybrid approach to optomechanics allows for enhanced effective interactions between ...
Dantan, Aurelien   +3 more
core   +1 more source

Savoir des affaires et marché du travail : la naissance des disciplines de gestion à Northwestern University [PDF]

open access: yes, 1999
National audienceComment rendre compte de l'institutionnalisation des savoirs ? Comment expliquer le moment où un ensemble de connaissances et de pratiques anciennes devient une discipline nouvelle, c'est à dire un corps d'expertise faisant l'objet non ...
Cochoy, Franck
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

Reporte de caso: exclusión de paternidad

open access: yesIatreia, 2010
Actualmente las pruebas de paternidad son realizadas empleando marcadores microsatélites tipo STR´s con el objetivo de establecer probabilidades de exclusión del 99.99% de acuerdo a la Ley 721 de2001 ó excluir a un presunto padre de la paternidad; por ...
William Usaquen   +8 more
doaj  

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