Results 71 to 80 of about 151,318 (265)

Interventional Mitral Valve Edge‐to‐Edge Repair in Patients Above 85 Years of Age

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Mitral valve transcatheter‐edge‐to‐edge repair (M‐TEER) is routinely performed in patients with severe mitral regurgitation (MR) at high operative risk, frequently including elderly patients. Patients ≥ 85 years, however, are frequently excluded in clinical studies.
Florian Jürgens, Florian Schindhelm, Mohammed Abusharekh, Jürgen Kampf, Matthias Totzeck, Fadi Al‐Rashid, Peter Lüdike, Tienush Rassaf, Amir A. Mahabadi   +8 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Conversations about measurement and evaluation in impact investing

African Evaluation Journal, 2018
In response to the enduring social, economic and environmental challenges facing the African continent and its population, development interventions are evolving to embrace new approaches, new partnerships and new means of achieving impact. One such area
Amreen Choda, Mishkah Teladia
doaj   +1 more source

Silica‐Supported Mononuclear Methyl‐Platinum Complexes Stabilized by Trimethylphosphine—Synthesis, Structure, and Reactions Under Reducing Conditions

Chemistry – A European Journal, EarlyView.
The article describes the synthesis and molecular transformations of a silica‐supported bis(phosphine)methylplatinum(II) complex under reactive (H2, CO) and inert gas atmospheres. The focus lies on the stabilizing effect of the sterically non‐demanding trimethylphosphine ligand, which alters the reactivity of the surface sites, compared to other ...
Lea S. Kopietz, Sven Schaefer, Oksana Storcheva, Gabriele Raudaschl‐Sieber, Johannes Bitzer, Wolfgang Kleist, Klaus Köhler   +6 more
wiley   +1 more source

Real-World Outcomes Among Patients in the United States Receiving Tafamidis for Transthyretin Amyloid Cardiomyopathy

Cardiology and Therapy
Introduction Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Tafamidis demonstrated efficacy in ATTR-CM clinical trials; however, real-world disease outcomes are not thoroughly characterized.
Daniel P. Judge, Margarita Udall, Andrew M. Rosen, Neil Lamarre, Elizabeth Nagelhout, Hanh Dung Dao, Mathew S. Maurer   +6 more
doaj   +1 more source

Power spectral density and the brain

Canadian Journal of Statistics, EarlyView.
Abstract Time series from M/EEG (magneto/electroencephalography) and ECoG (electrocorticography) recordings are common sources of information about brain function. The power spectral density (PSD) preserves much of this information, up to second order. In the current decade, a burst of brain diagnostics using the slope of log(PSD) has appeared.
Priscilla E. Greenwood, Sveinung Erland, Lawrence M. Ward   +2 more
wiley   +1 more source

Coastal Genesis

Coastal Engineering 1988, 1988
In order to investigate the effect of enchanced sea level rising (greenhouse effect), of sand mining in the North sea and the largescale effects of beach nourishment, the Rijkswaterstaat (Governmental Board for Ways, Waterways and Harbours) started the project "Coastal Genesis".
J.H. De Vroeg, E.S.P. Smit, W.T. Bakker
openaire   +2 more sources

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Real-World Treatment Patterns, Sequencing, and Outcomes in Patients with Locally Advanced or Metastatic Urothelial Carcinoma Receiving Avelumab First-Line Maintenance in the United States

Current Oncology
For patients with locally advanced/metastatic urothelial carcinoma (la/mUC), first-line (1L) treatment with platinum-based chemotherapy (PBC) followed by avelumab 1L maintenance (1LM) is a recommended therapy per treatment guidelines in patients without ...
Helen H. Moon, Mairead Kearney, Seyed Hamidreza Mahmoudpour, Chiemeka Ike, Valerie Morris, Andrew Rava, Sonia Kim, Haiyan Sun, Marley Boyd, Gabriel Gomez Rey   +9 more
doaj   +1 more source

Different Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis

Frontiers in Immunology, 2017
A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes and subclasses with different functional properties ...
Kazutaka Kitaura, Hiroshi Yamashita, Hitomi Ayabe, Tadasu Shini, Tadasu Shini, Takaji Matsutani, Ryuji Suzuki, Ryuji Suzuki   +7 more
doaj   +1 more source